Evidence map›Paper›PMID 38913224›Full record

ArticleTissue engineering and regenerative medicine2024

Adipose-Derived Mesenchymal Stem Cells and Their Derived Epidermal Progenitor Cells Conditioned Media Ameliorate Skin Aging in Rats.

Omar I Badr, Aya Anter, Ihab Magdy, Marvellous Chukueggu, Moamen Khorshid, Mohamed Darwish, Mohamed Farrag, Menna Elsayed, Youmna Amr, Yomna Amgad and 2 more

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Article in Tissue engineering and regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Omar I BadrPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Aya Anter *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Ihab Magdy *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Marvellous Chukueggu *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Moamen Khorshid *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Mohamed Darwish *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Mohamed Farrag *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Menna Elsayed *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Youmna Amr *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Yomna Amgad *Final Year Pharmacy students, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Tasnim MahmoudPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Mohamed M KamalPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt. Mohamed.Kamal@bue.edu.eg.ORCID 0000-0002-6004-2590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin alterations are among the most prominent signs of aging, and they arise from both intrinsic and extrinsic factors that interact and mutually influence one another. The use of D-galactose as an aging model in animals has been widely employed in anti-aging research. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) are particularly promising for skin anti-aging therapy due to their capacity for effective re-epithelization and secretion of various growth factors essential for skin regeneration. Accordingly, we aimed to examine the potential utility of Ad-MSCs as a therapy for skin anti-aging.

methodsIn this study, we isolated and characterized adipose-derived mesenchymal stem cells (Ad-MSCs) from the epididymal fat of male Sprague Dawley rats. We assessed the in vitro differentiation of Ad-MSCs into epidermal progenitor cells (EPCs) using ascorbic acid and hydrocoritsone. Additionally, we induced skin aging in female Sprague Dawley rats via daily intradermal injection of D-galactose over a period of 8 weeks. Then we evaluated the therapeutic potential of intradermal transplantation of Ad-MSCs and conditioned media (CM) derived from differentiated EPCs in the D-galactose-induced aging rats. Morphological assessments, antioxidant assays, and histopathological examinations were performed to investigate the effects of the treatments.

resultsOur findings revealed the significant capability of Ad-MSCs to differentiate into EPCs. Notably, compared to the group that received CM treatment, the Ad-MSCs-treated group exhibited a marked improvement in morphological appearance, antioxidant levels and histological features.

conclusionsThese results underscore the effectiveness of Ad-MSCs in restoring skin aging as a potential therapy for skin aging.

Indexed as

Adipose TissueCell DifferentiationMesenchymal Stem CellsRats, Sprague-DawleySkin AgingAnimalsCulture Media, ConditionedEpidermal CellsFemaleGalactoseMaleMesenchymal Stem Cell TransplantationRatsCulture Media, ConditionedGalactoseAdipose tissued-galactoseEpidermal progenitor cellsMesenchymal stem cellsRegenerative medicineSkin aging

Identifiers

PMID38913224
PMCPMC11286614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.