Evidence map›Paper›PMID 38913131›Full record

ArticleJournal of ultrasound2024

The efficacy of hyaluronic acid fragments with amino acid in combating facial skin aging: an ultrasound and histological study.

Antonio Scarano, E Qorri, A Sbarbati, S A Gehrke, Alessio Frisone, D Amuso, Sergio Rexhep Tari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonio ScaranoDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Strada Marcello Mucci 38/B, 66100, Chieti, Italy. ascarano@unich.it.ORCID http://orcid.org/0000-0003-1374-6146
E QorriDepartment of Dentistry, Faculty of Medical Sciences, Albanian University, 1001, Tirana, Albania.
A SbarbatiDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, School of Medicine, University of Verona, Verona, Italy.
S A GehrkeDepartment of Research, Bioface/PgO/UCAM, Montevideo, Uruguay.
Alessio FrisoneDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Strada Marcello Mucci 38/B, 66100, Chieti, Italy.
D AmusoDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, School of Medicine, University of Verona, Verona, Italy.
Sergio Rexhep TariDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Strada Marcello Mucci 38/B, 66100, Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious techniques have been employed in aesthetic medicine to combat skin aging, in particular that of the facial region. Hyaluronic acid is utilized to enhance moisture levels and extracellular matrix molecules. This study aims to histologically assess the effects of low molecular weight hyaluronic acid fragments combined with amino acids (HAAM) on facial skin rejuvenation through intradermal microinjections.

methodsA total of twenty women, with an average age of 45 and ranging from 35 to 64 years old, participated in the study, including 8 in menopause and 12 in the childbearing age group. Mesotherapy was used to administer HAAM to the patients. Prior to and three months after the treatment, each patient underwent small circular punch biopsies. Ultrasound examinations were conducted using B-mode, capturing 2D images in longitudinal or transverse orientations with frequencies ranging from 5 to 13 Mega-hertz (MY LAB X8, ESAOTE, Genova, Italy). A total of 60 ultrasound examinations were taken, with 30 collected before treatment and 30 after treatment.

resultsThe histological analysis demonstrates an increase in fibroblast activity resulting in the production of Type III reticular collagen, as well as an increased number of blood vessels and epidermal thickness. However, the analysis of ultrasound data before and after treatment showed no statistical difference in skin thickness in malar area, chin and mandibular angle.

conclusionsHistological assessments indicate that subcutaneous infiltration of HAAM has a substantial impact on the dermis of facial skin.

Indexed as

Amino AcidsFaceHyaluronic AcidRejuvenationSkin AgingUltrasonographyAdultCosmetic TechniquesFemaleHumansMesotherapyMiddle AgedSkinTreatment OutcomeAmino AcidsHyaluronic AcidAmino acidFibroblastHyaluronic acidHyaluronic acid fragmentsSkin agingUltrasound

Identifiers

PMID38913131
PMCPMC11333785

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.