Evidence map›Paper›PMID 38912902›Full record

Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2024

Testing a Population-Based Outreach Intervention for Ovarian Cancer Survivors to Encourage their Close Relatives to Consider Genetic Counseling.

Yue Guan, Colleen M McBride, Jingsong Zhao, Rebecca D Pentz, Cam Escoffery, Yuan Liu, Yichun Cao, Weihua An, James A Shepperd, Kevin C Ward

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04927013 (Testing a Low Cost Population- and Theory-Based Outreach Intervention to Engage Ovarian Cancer Survivors and Their Close Relatives to Consider Genetic Services), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04927013 nacompletednot on this map

Testing a Low Cost Population- and Theory-Based Outreach Intervention to Engage Ovarian Cancer Survivors and Their Close Relatives to Consider Genetic Services

TypeinterventionalSponsorEmory UniversityRan2021 to 2023Enrolled2,331ConditionsOvarian CancerArmsMessage-based Outreach Intervention for Survivors, Standard Outreach for Survivors, Message-based Outreach Intervention for Close Relatives, Standard Outreach for Close Relatives
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue GuanDepartment of Behavioral, Social and Health Education Sciences, Emory University, Atlanta, Georgia.ORCID 0000-0001-6377-4626
Colleen M McBrideDepartment of Behavioral, Social and Health Education Sciences, Emory University, Atlanta, Georgia.ORCID 0000-0001-6061-9815
Jingsong ZhaoDepartment of Behavioral, Social and Health Education Sciences, Emory University, Atlanta, Georgia.ORCID 0000-0002-0409-6164
Rebecca D PentzDepartment of Hematology and Oncology, Winship Cancer Institute, Emory School of Medicine, Atlanta, Georgia.ORCID 0000-0003-4338-6663
Cam EscofferyDepartment of Behavioral, Social and Health Education Sciences, Emory University, Atlanta, Georgia.ORCID 0000-0003-4445-009X
Yuan LiuDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health & Winship Cancer Institute, Emory University, Atlanta, Georgia.ORCID 0000-0001-8926-3058
Yichun CaoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health & Winship Cancer Institute, Emory University, Atlanta, Georgia.ORCID 0009-0004-6001-855X
Weihua AnDepartment of Sociology and Department of Quantitative Theory and Methods, Emory University, Atlanta, Georgia.ORCID 0000-0003-0334-2930
James A ShepperdDepartment of Psychology, University of Florida, Gainesville, Florida.ORCID 0000-0002-5329-6760
Kevin C WardDepartment of Epidemiology, Emory University, Atlanta, Georgia.ORCID 0000-0001-5893-6192

Funding

Testing a Low Cost Population- and Theory-Based Outreach Intervention to Engage Ovarian Cancer Survivors and their Close Relatives to Consider Genetic ServicesU01CA240581 · NCI · EMORY UNIVERSITY · PI GUAN, YUE · 2020 to 2023
$2.6M
National Cancer Institute (NCI) U01CA24058NCI NIH HHS U01 CA240581
6 · The paper itself

Abstract

backgroundMost relatives of women with ovarian cancer are unaware of their increased risk for cancer and their eligibility for genetic counseling. State cancer registries offer a platform to communicate about inherited risk to this population.

methodsWe conducted a two-arm randomized trial to test a theory-based communication intervention-Your Family Connects (YFC)-compared to the standard Georgia Cancer Registry (GCR) contact. A total of 1,938 eligible ovarian cancer survivors were randomly assigned to either the YFC arm (n = 969) or the Standard Care arm (n = 969). We assessed the number of ovarian cancer survivors and their close relatives who logged on to the study website by arm.

resultsSurvivor reach was significantly higher in the Standard Care arm than YFC (20.8% vs. 15.2%, respectively; P < 0.001). However, reach to relatives was limited to listed relatives in the YFC arm (n = 20, 13.2%), with little participation from those in the Standard Care arm (n = 1, 0.4%). Pooling across arms, minority race, longer time since diagnosis, and older age were all significantly associated with a decreased likelihood that the survivor accessed the website.

conclusionsThe YFC intervention showed lower effectiveness for engaging survivors but was more effective than Standard Care in engaging at-risk relatives. Other factors (e.g., time since diagnosis) associated with lower reach must be considered in refining future outreach approaches. IMPACT: Partnering with a state cancer registry to foster family communication about inherited cancer risk is feasible but the possibility for broad population reach warrants further testing.

Indexed as

Cancer SurvivorsGenetic CounselingOvarian NeoplasmsAdultAgedFamilyFemaleGenetic Predisposition to DiseaseHumansMiddle AgedRegistries

Identifiers

PMID38912902
PMCPMC11369613

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.