ArticlemBio2024
A
Abstract read
In one paragraph
Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Pan-African hybridization of PfSPZ increases antigenic diversity and replicative capacity for malaria vaccine design.JCI insight · 2026Article
- New thinking for the next generation of antimalarials.EMBO molecular medicine · 2026Review
- A Multidimensional Analysis of the Bimodal Piperaquine Response inbioRxiv : the preprint server for biology · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Impact of intensive control on malaria population genomics under elimination settings in Southeast Asia.Nature microbiology · 2026Article
- Changing genetic profiles ofAntimicrobial agents and chemotherapy · 2026Article
- LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity.PLoS pathogens · 2026Article
- hmmibd-rs: an enhanced hmmIBD implementation for parallelizable identity-by-descent detection from large-scale Plasmodium genomic data.Malaria journal · 2026Article
- Frequencies of molecular markers of drug resistance in the context of two different Seasonal Malaria Chemoprevention (SMC) treatment regimens in the Koulikoro health district, Mali.Antimicrobial agents and chemotherapy · 2025Article
- Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay.Malaria journal · 2025Article
- The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.PLoS pathogens · 2025Article
- Low prevalence of copy number variation in pfmdr1 and pfpm2 in Plasmodium falciparum isolates from southern Angola.Malaria journal · 2025Article
- Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana.PLoS pathogens · 2024Article
- Temporal and spatial dynamics ofbioRxiv : the preprint server for biology · 2024Article
- IncompleteFrontiers in cellular and infection microbiology · 2024Article
Corrections and comments
- Update ofA2023
Authors and funding
25 authors.
John KaneDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0003-4917-7205
Xue LiDisease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Sudhir KumarCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-2847-393X
Katrina A Button-SimonsDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Katelyn M Vendrely BrennemanDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Haley DahlhoffDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Mackenzie A C SievertDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Lisa A CheckleyDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Douglas A ShoueDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Puspendra P SinghDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Biley A AbatiyowCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Meseret T HaileCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Shalini NairDisease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Ann ReyesDisease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Rupam TripuraMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Thomas J PetoMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Dysoley LekNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Angana MukherjeeDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.
Stefan H I KappeCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Mehul DhordaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Standwell C NkhomaBEI Resources, American Type Culture Collection (ATCC), Manassas, Virginia, USA.
Ian H CheesemanHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Ashley M VaughanCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Timothy J C AndersonDisease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.ORCID 0000-0002-0191-0204
Michael T FerdigDepartment of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0003-3516-9829
Funding
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MSystems genetics of artemisinin resistanceP01AI127338 · NIAID · UNIVERSITY OF NOTRE DAME · PI Michael T Ferdig, Ashley M Vaughan · 2017 to 2026
$21.3MMAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUMR01AI048071 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Tim J Anderson · 2000 to 2026
$8.4MMapping Drug Resistance Genes in Plasmodium falciparumR37AI048071 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2012 to 2021
$7.9MMOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–HHS | National Institutes of Health (NIH) AI048071HHS | National Institutes of Health (NIH) AI127338NCRR NIH HHS C06 RR013556NIAID NIH HHS P01 AI127338NIAID NIH HHS R01 AI048071NIAID NIH HHS R37 AI048071NIH HHS P51 OD011133Texas Biomedical Research Institute (Texas Biomed) 20-04866Wellcome TrustWellcome Trust of Great Britain 099992/Z/12/Z
Abstract
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the
Indexed as
AntimalarialsAspartic Acid EndopeptidasesDrug ResistanceMembrane Transport ProteinsPlasmodium falciparumProtozoan ProteinsQuinolinesAllelesCambodiaHumansMalaria, FalciparumMutationPiperazinesAntimalarialsAspartic Acid EndopeptidasesMembrane Transport ProteinsPfCRT protein, Plasmodium falciparumpiperaquinePiperazinesplasmepsinplasmepsin IIProtozoan ProteinsQuinolinesdrug resistance evolutiongenetic crossmalariapiperaquinePlasmodium falciparum
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.