Evidence map›Paper›PMID 38912690›Full record

ReviewDiabetes2024

The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications-2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum.

Mariana Byndloss, Suzanne Devkota, Frank Duca, Jan Hendrik Niess, Max Nieuwdorp, Marju Orho-Melander, Yolanda Sanz, Valentina Tremaroli, Liping Zhao

Abstract readReview
In one paragraph

Review in Diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Expanding the understanding of insulin resistance in brain and periphery.Trends in endocrinology and metabolism: TEM · 2026
    Review
  9. Article
  10. The role of GABA in type 1 diabetes.Frontiers in endocrinology · 2024
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariana ByndlossVanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2122-4156
Suzanne DevkotaHuman Microbiome Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-5575-9362
Frank DucaUniversity of Arizona, Tucson, AZ.ORCID 0000-0003-1760-4081
Jan Hendrik NiessDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID 0000-0001-6902-5650
Max NieuwdorpDepartment of Internal and Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID 0000-0002-1926-7659
Marju Orho-MelanderDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.ORCID 0000-0002-3578-2503
Yolanda SanzInstitute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Valencia, Spain.ORCID 0000-0002-1615-1976
Valentina TremaroliWallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-9150-4233
Liping ZhaoDepartment of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ.ORCID 0000-0001-9694-7140

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Is Obesity an Infectious Disease?: Gut bacterial and fungal translocation as an underappreciated driver of visceral adipose expansion.DP1DK130687 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI DEVKOTA, SUZANNE · 2021 to 2025
$4.0M
Obesogenic diet-induced intestinal epithelium repair responses link dysbiosis and cardiovascular diseaseR01DK131104 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Mariana Xavier Byndloss · 2022 to 2026
$2.4M
Role of microbiota, host genetics and mesenteric adipose in Crohn's disease fibrosis and post-op recurrence.R01DK123446 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI DEVKOTA, SUZANNE · 2020 to 2024
$2.3M
DFN-DON 2020 (2020.10.002)European Union’s Innovative Medicine Initiative 875534NIDDK NIH HHS 1DP1 DK130687NIDDK NIH HHS DP1 DK130687NIDDK NIH HHS R01 DK123446NIDDK NIH HHS R01 DK131104NIEHS NIH HHS P30 ES005022Novo Nordisk FoundationSevero Ochoa Center of Excellence CEX2021-001189-S/10.13039/501100011033Spanish Ministry of Science, Innovation and Universities MICIU/AEI PID2020-119536RB-I00Swiss National Science Foundation (SNSF) 310030_219210ZONMW-VICI 2020 (09150182010020)
6 · The paper itself

Abstract

This article summarizes the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in the field of the intestinal microbiome and metabolism. Their conclusions were as follows: 1) the GM may be involved in the pathophysiology of type 2 diabetes, as microbially produced metabolites associate both positively and negatively with the disease, and mechanistic links of GM functions (e.g., genes for butyrate production) with glucose metabolism have recently emerged through the use of Mendelian randomization in humans; 2) the highly individualized nature of the GM poses a major research obstacle, and large cohorts and a deep-sequencing metagenomic approach are required for robust assessments of associations and causation; 3) because single-time point sampling misses intraindividual GM dynamics, future studies with repeated measures within individuals are needed; and 4) much future research will be required to determine the applicability of this expanding knowledge to diabetes diagnosis and treatment, and novel technologies and improved computational tools will be important to achieve this goal.

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeHumansTranslational Research, Biomedical

Identifiers

PMID38912690
PMCPMC11333376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.