Fabrication of CMC/PVA/Dextrin-Based Polymeric Membrane for Controlled Release of Cefixime With Enhanced Antibacterial Activity.

Arif Nazir, Mazhar Abbas, Dure Najaf Iqbal, Fadia Ameen, Samiah H Al-Mijalli, Naveed Ahmad, Munawar Iqbal

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Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Arif NazirDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.ORCID https://orcid.org/0000-0002-9412-6100

Mazhar AbbasDepartment of Basic Science (Section Biochemistry), University of Veterinary and Animals Science Lahore, Jhang, Pakistan.

Dure Najaf IqbalDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.

Fadia AmeenDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.

Samiah H Al-MijalliDepartment of Biology, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Naveed AhmadDepartment of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan.ORCID https://orcid.org/0000-0002-5847-903X

Munawar IqbalSchool of Chemistry, University of the Punjab, Lahore, Pakistan.ORCID https://orcid.org/0000-0001-7393-8065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study focuses on the investigation of the significance of polymers in drug delivery approaches. The carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA) and dextrin-based hydrogel membrane were prepared and employed for the sustained release of third-generation oral antibiotic (cefixime). Different proportions of CMC, PVA and dextrin were blended and hydrogel membranes were fabricated via solvent casting method. The prepared membrane was characterized by FTIR, SEM, UV-visible, TGA and swelling analysis. Cefixime drug was incorporated in the CMC/PVA/dextrin matrix and drug release was investigated. The sustained release of the tested drug (cefixime) was investigated and the drug was released in 120 min in the phosphate-buffered saline (PBS) solution. The antibacterial activity of the prepared membrane was promising against

Indexed as

antibacterial activitycefiximecontrolled drug releasecytotoxicitypolymeric membranes

Identifiers

PMID38912332

DOI10.1177/15593258241264951

PMCPMC11193932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.