ArticleFrontiers in nutrition2024
Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Effect of Vitamin D3 Supplementation on Vitamin D Status and Associated Health Outcomes in Children: A Randomized Controlled Trial.The Journal of nutrition · 2026Trial
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study.Frontiers in nutrition · 2026Article
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Authors and funding
7 authors.
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Abstract
Introduction: Vitamin D plays a major role in the musculoskeletal and immune system. Understanding the comprehensive mechanism of vitamin D receptors and the enzyme of vitamin D induction (CYP2R1) and inhibition (CYP24A1) in its metabolism is interesting. This study aims to understand vitamin D metabolism in Indonesian pediatrics, specifically in Jakarta, which has abundant sun exposure. Methodology: A cross-sectional study with comparative, correlative, and multivariate analysis on vitamin D, vitamin D receptor, CYP2R1, and CYP24A1 levels was conducted on 46 children with no known morbidity. Result: Subjects were mostly male (52.2%), age group of 2-6 years (34.8%), and had sufficient vitamin D status (43.5%, median 27.55 ng/mL). Age was found to have a negative correlation with vitamin D levels ( Conclusion: Vitamin D levels decrease with the increase in age. Vitamin D receptor level has an inline-level progression with vitamin D level. CYP2R1 and CYP24A1 suggest a directly proportional relationship. Vitamin D screening and supplementation in children older than 2 years old are suggested.
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