Evidence map›Paper›PMID 38912207›Full record

ArticleFrontiers in cellular and infection microbiology2024

Utilization of the Shensheng-Piwen changed medicinal powder extracts combines metal-organic frameworks as an antibacterial agent.

Haiqun Jin, Xiujun Zhang, Xiaoqing Ma, Xin Meng, Zhenguang Lin, Xiaoyuan Li, Guojie Hu, Yao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haiqun JinState Key Laboratory of Medicinal Chemical Biology, Nankai University, Haihe Laboratory of Synthetic Biology, Tianjin, China.
Xiujun ZhangTianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Xiaoqing MaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Marine Biomedical Research Institute of Qingdao, Qingdao, China.
Xin MengKey Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Zhenguang LinShandong Academy of Pharmaceutical Sciences, Jinan, China.
Xiaoyuan LiDepartment of Traditional Chinese Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.
Guojie HuDepartment of Traditional Chinese Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.
Yao ChenState Key Laboratory of Medicinal Chemical Biology, Nankai University, Haihe Laboratory of Synthetic Biology, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Widespread opportunistic pathogens pose a serious threat to global health, particularly in susceptible hospital populations. The escalating crisis of antibiotic resistance highlights the urgent need for novel antibacterial agents and alternative treatment approaches. Traditional Chinese Medicine (TCM) and its compounds have deep roots in the treatment of infectious diseases. It has a variety of active ingredients and multi-target properties, opening up new avenues for the discovery and development of antimicrobial drugs. Methods: This study focuses on assessing the efficacy of the Shensheng-Piwen changed medicinal powder (SPC) extracts against opportunistic pathogen infections by broth microdilution and agar disc diffusion methods. Additionally, biofilm inhibition and eradication assays were performed to evaluate the antibiofilm effects of SPC extracts. Results: Metabolite profiles were analyzed by LC-MS. Furthermore, the potential synergistic effect between SPC and Metal-Organic Framework (MOF) was investigated by bacterial growth curve analysis. The results indicated that the SPC extracts exhibited antibacterial activity against Discussion: In conclusion, the present study highlights the potential of SPC extracts as a novel antibacterial agent against

Indexed as

Anti-Bacterial AgentsBiofilmsDrugs, Chinese HerbalMetal-Organic FrameworksMicrobial Sensitivity TestsStaphylococcus aureusChromatography, LiquidDrug SynergismHumansPowdersAnti-Bacterial AgentsDrugs, Chinese HerbalMetal-Organic FrameworksPowdersantimicrobialbiofilmsinfectionsmetabolomicsShensheng-Piwen changed medicinal powdersynergy

Identifiers

PMID38912207
PMCPMC11193333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.