Evidence map›Paper›PMID 38912194›Full record

ArticleThe Journal of clinical and aesthetic dermatology2024

Pharmacological Management and Potentially Inappropriate Prescriptions for Patients with Acne.

Luis Fernando Valladales-Restrepo, Laura Sofia Serna-Echeverri, Juan Darío Franco-Ramírez, Katherine Vargas-Diaz, Nathalia Marcela Peña-Verjan, Jorge Enrique Machado-Alba

Abstract read
In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luis Fernando Valladales-RestrepoDrs. Valladales-Restrepo, Serna-Echeverri, Franco-Ramírez, and Machado-Alba are with the Grupo de Investigación en Farmacoepidemiologia y Farmacovigilancia at the Universidad Tecnológica de Pereira-Audifarma SA in Pereira, Colombia.
Laura Sofia Serna-EcheverriDrs. Valladales-Restrepo, Serna-Echeverri, Franco-Ramírez, and Machado-Alba are with the Grupo de Investigación en Farmacoepidemiologia y Farmacovigilancia at the Universidad Tecnológica de Pereira-Audifarma SA in Pereira, Colombia.
Juan Darío Franco-RamírezDrs. Valladales-Restrepo, Serna-Echeverri, Franco-Ramírez, and Machado-Alba are with the Grupo de Investigación en Farmacoepidemiologia y Farmacovigilancia at the Universidad Tecnológica de Pereira-Audifarma SA in Pereira, Colombia.
Katherine Vargas-DiazDrs. Vargas-Diaz and Peña-Verjan are with Semillero de Investigación en Farmacología Geriátrica, and the Grupo de investigación Biomedicina of the Faculty of Medicine at the Fundación Universitaria Autonoma de las Americas in Pereira, Colombia.
Nathalia Marcela Peña-VerjanDrs. Vargas-Diaz and Peña-Verjan are with Semillero de Investigación en Farmacología Geriátrica, and the Grupo de investigación Biomedicina of the Faculty of Medicine at the Fundación Universitaria Autonoma de las Americas in Pereira, Colombia.
Jorge Enrique Machado-AlbaDrs. Valladales-Restrepo, Serna-Echeverri, Franco-Ramírez, and Machado-Alba are with the Grupo de Investigación en Farmacoepidemiologia y Farmacovigilancia at the Universidad Tecnológica de Pereira-Audifarma SA in Pereira, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Acne is a chronic inflammatory disease that involves the pilosebaceous follicle. Its pharmacological treatment involves topical and systemic medications, but a heterogeneous group of drugs may exacerbate or induce skin lesions. The aim of this study was to identify the pharmacological management and medications related to the exacerbation of skin lesions in patients diagnosed with acne. Methods: This was a cross-sectional study that identified the outpatient medication prescription patterns of patients with acne from a dispensing database of 8.5 million members of the Colombian Health System. Sociodemographic and pharmacological variables and the identification of prescriptions that were potentially inappropriate due to the risk of worsening acne were considered. Results: A total of 21,604 patients with acne were identified. Median age was 20.8 years (interquartile range: 17.3-27.3 years), and 60.7 percent were female. Treatment mainly involved antibiotics (79.9% of patients), especially doxycycline (66.0%), and retinoids (55.7%). A total of 17.2 percent of patients had potentially inappropriate prescriptions, predominantly progestogens with androgenic properties (8.9%). Female patients (odds ratio [OR]: 3.55; 95% confidence interval [CI]:3.24-3.90) and patients with pathologies such as systemic lupus erythematosus (OR: 18.61; 95% CI: 7.23-47.93) and rheumatoid arthritis (OR: 10.80; 95% CI: 5.02-23.23) were more likely to receive inappropriate prescriptions, and the risk increased with each year of life (OR: 1.02; 95% CI: 1.02-1.03). Limitations: Access to medical records was not obtained to verify clinical characteristics of acne. Conclusion: Patients with acne are excessively treated with systemic antibiotics, counter to clinical practice guidelines. Approximately one-fifth of these patients received some potentially inappropriate medication that could exacerbate their skin lesions.

Indexed as

Acne vulgarisantibacterial agentscombined contraceptivescontraceptivesoral contraceptivespharmacoepidemiologyretinoids

Identifiers

PMID38912194
PMCPMC11189648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.