Evidence map›Paper›PMID 38911873›Full record

ArticleAddiction neuroscience2024

Behavioral and neuronal extracellular vesicle biomarkers associated with nicotine's enhancement of the reinforcing strength of cocaine in female and male monkeys.

Mia I Allen, Bernard N Johnson, Ashish Kumar, Yixin Su, Sangeeta Singh, Gagan Deep, Michael A Nader

Abstract read
In one paragraph

Article in Addiction neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Cocaine self-administration in adult female and male rhesus monkeys: longitudinal comparison with adolescent behavior and role of early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Article
  5. Longevity and Catheter-Related Infection Rates in Nonhuman Primates with Chronic Indwelling Intravenous Catheters.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mia I AllenDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Bernard N JohnsonDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Ashish KumarDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Yixin SuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Sangeeta SinghDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Gagan DeepCenter for Addiction Research, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Michael A NaderDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, United States.

Funding

Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male MonkeysR01DA017763 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael A Nader · 2004 to 2026
$9.8M
Neuronal exosomes in cocaine abuse and treatment response in socially housed monkeysR01DA049267 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, NADER, MICHAEL A · 2019 to 2023
$1.9M
The Neurobiology of Drug AbuseT32DA041349 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SARA RAULERSON JONES · 2017 to 2026
$1.8M
Kappa Opioid Receptor Availability, Social Rank, and Cocaine Self-Administration in Female and Male MonkeysF31DA053776 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JOHNSON, BERNARD N · 2022 to 2024
$117k
NIDA NIH HHS F31 DA053776NIDA NIH HHS R01 DA017763NIDA NIH HHS R01 DA049267NIDA NIH HHS T32 DA041349
6 · The paper itself

Abstract

While the majority of people with cocaine use disorders (CUD) also co-use tobacco/nicotine, most preclinical cocaine research does not include nicotine. The present study examined nicotine and cocaine co-use under several conditions of intravenous drug self-administration in monkeys, as well as potential peripheral biomarkers associated with co-use. In Experiment 1, male rhesus monkeys (

Indexed as

Cocaine use disorderDrug choiceExtracellular vesiclesImpulsive ChoiceNicotineNonhuman PrimatesReinforcing strengthSelf-administration

Identifiers

PMID38911873
PMCPMC11192513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.