Evidence map›Paper›PMID 38911867›Full record

ArticleFrontiers in immunology2024

Zhongqun Yue, Yue Zhu, Teng Chen, Tingting Feng, Ying Zhou, Jiaojiao Zhang, Ning Zhang, Jing Yang, Gang Luo, Zuhua Wang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Recent advances inFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhongqun Yue *College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yue Zhu *College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Teng ChenCollege of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Tingting FengCollege of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Ying ZhouCollege of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Jiaojiao ZhangCollege of Food and Health, Zhejiang A&F University, Hangzhou, China.
Ning ZhangSchool of Acupuncture-Moxibustion and Tuina of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Jing YangCollege of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Gang LuoKey Laboratory of Medical Microbiology and Parasitology and Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
Zuhua WangCollege of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin E, which is also known as tocopherol, is a compound with a polyphenol structure. Its esterified derivative, Vitamin E succinate (VES), exhibits unique anticancer and healthcare functions as well as immunomodulatory effects. Natural polysaccharides are proved to be a promising material for nano-drug delivery systems, which show excellent biodegradability and biocompatibility. In this study, we employed a novel Methods: BSP-VES polymer was synthesized through esterification and its structure was confirmed using 1H NMR. AG@BSP-VES was prepared via the dialysis method and the drug loading, entrapment efficiency, stability, and safety were assessed. Furthermore, the tumor targeting ability of AG@BSP-VES was evaluated through targeted cell uptake and Results: In this study, we successfully loaded AG into BSP-VES micelles (AG@BSP-VES), which exhibited good stability, biosafety and sustained release effect. In addition, AG@BSP-VES also showed excellent internalization capability into CT26 cells compared with NCM460 cells Conclusion: The study provides a meaningful new idea and method for application in drug delivery system and targeted treatment of colon cancer based on natural polysaccharides.

Indexed as

Colonic NeoplasmsDiterpenesMicellesPolysaccharidesAnimalsAntineoplastic AgentsCell Line, TumorDrug CarriersDrug Delivery SystemsHumansMiceMice, Inbred BALB CMice, NudeNanoparticle Drug Delivery SystemNanoparticlesXenograft Model Antitumor AssaysandrographolideAntineoplastic AgentsDiterpenesDrug CarriersMicellesNanoparticle Drug Delivery Systempolysaccharide b, Bletilla striataPolysaccharidesandrographolideBletilla striata polysaccharidecolon cancernano-micellepolymer

Identifiers

PMID38911867
PMCPMC11190162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.