ArticleFrontiers in psychiatry2024
Bidirectional causal relational between frailty and mental illness: a two-sample Mendelian randomization study.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Clinical sub-phenotypes of co-occurring metabolic syndrome and pre-frailty and their associated factors in older adults: findings from Whitehall II study.Frontiers in medicine · 2026Article
- Insulin resistance indicators in aortic disease: A large cohort study.Clinical and translational medicine · 2026Article
- Viral infections and risk of mental illness: A Mendelian randomization study.Brain, behavior, & immunity - health · 2025Article
- Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study.BJPsych open · 2025Article
- Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.BMC psychiatry · 2024Article
- Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.Aging clinical and experimental research · 2024Article
- Dual trajectories of social participation and frailty in Chinese older adults: a longitudinal study based on CLHLS from 2008 to 2018.Frontiers in public health · 2024Article
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Authors and funding
10 authors.
Funding
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Abstract
Background: Frailty has been associated with mental illness (MI) observational studies, but the causal relationship between these factors remains uncertain. We aimed to assess the bidirectional causality between frailty and MI by two-sample Mendelian randomization (MR) analyses. Methods: To investigate the causal relationship among them, summary statistics of frailty index (FI) and six types of MI: anxiety, depression, affective disorder, mania, schizophrenia, and obsessive-compulsive disorder (OCD) were included in this MR study. This MR analysis was performed using inverse variance weighting (IVW), MR-Egger regression, and weighted median. The stability of the results was evaluated using Cochran's Q test, MR-Egger intercept test, Funnel Plots, and leave-one-out analysis. Results: Genetic predisposition to FI was significantly associated with increased anxiety (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.13-2.33, Conclusion: The MR results suggest a potential bidirectional causal relationship between FI and anxiety, depression, and affective disorder. Schizophrenia was found to be associated with a higher risk of FI. The evidence was insufficient to support a causal relationship between Fl and other Ml. These findings offer new insights into the development of effective management strategies for frailty and MI.
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