ArticleJournal of mood and anxiety disorders2024
Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment.
Article in Journal of mood and anxiety disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Temporal reorganization of maternal care during early life stress in mice.Neurobiology of stress · 2026Article
- Developmental origins of ADHD: sex-specific influences of early life unpredictability on symptom profiles.Journal of developmental origins of health and disease · 2026Article
- Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.bioRxiv : the preprint server for biology · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Provider and Parent Perspectives on Pediatric Screening for Research on Early Life Adversity.Health education & behavior : the official publication of the Society for Public Health Education · 2025Article
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Strengthening through adversity: The hormesis model in developmental psychopathology.Development and psychopathology · 2024Article
- The relationship between unpredictability in childhood and depression among college students: the mediating roles of coping style and resilience.BMC psychology · 2024Article
- Social support mediates the effects of childhood unpredictability on anhedonia: A retrospective investigation in an online adult community sample.Journal of mood and anxiety disorders · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
High unpredictability has emerged as a dimension of early-life adversity that may contribute to a host of deleterious consequences later in life. Early-life unpredictability affects development of limbic and reward circuits in both rodents and humans, with a potential to increase sensitivity to stressors and mood symptoms later in life. Here, we examined the extent to which unpredictability during childhood was associated with changes in mood symptoms (anhedonia and general depression) after two adult life stressors, combat deployment and civilian reintegration, which were assessed ten years apart. We also examined how perceived stress and social support mediated and /or moderated links between childhood unpredictability and mood symptoms. To test these hypotheses, we leveraged the Marine Resiliency Study, a prospective longitudinal study of the effects of combat deployment on mental health in Active-Duty Marines and Navy Corpsman. Participants (
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Registered trials
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