ArticleNeurobiology of language (Cambridge, Mass.)2024
Approaches to Measuring Language Lateralisation: An Exploratory Study Comparing Two fMRI Methods and Functional Transcranial Doppler Ultrasound.
Article in Neurobiology of language (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- NEBULA101: an open dataset for the study of language aptitude in behaviour, brain structure and function.Scientific data · 2025Article
- The reliability of bilateral cerebral laterality for word generation: Who is left in the middle?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evidence for a compensatory relationship between left- and right-lateralized brain networks.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Revisiting atypical language lateralization in dyslexia.Brain communications · 2025Article
- Brain Laterality in Dyslexia Seen during Literacy Development and Early Training.Brain sciences · 2024Article
- What does lack of language lateralization signify? Evidence of fluctuating asymmetry rather than hemispheric equipoise on non-lateralized tasks.Royal Society open science · 2024Article
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3 authors.
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Abstract
In this exploratory study we compare and contrast two methods for deriving a laterality index (LI) from functional magnetic resonance imaging (fMRI) data: the weighted bootstrapped mean from the LI Toolbox (toolbox method), and a novel method that uses subtraction of activations from homologous regions in left and right hemispheres to give an array of difference scores (mirror method). Data came from 31 individuals who had been selected to include a high proportion of people with atypical laterality when tested with functional transcranial Doppler ultrasound (fTCD). On two tasks, word generation and semantic matching, the mirror method generally gave better agreement with fTCD laterality than the toolbox method, both for individual regions of interest, and for a large region corresponding to the middle cerebral artery. LI estimates from this method had much smaller confidence intervals (CIs) than those from the toolbox method; with the mirror method, most participants were reliably lateralised to left or right, whereas with the toolbox method, a higher proportion were categorised as bilateral (i.e., the CI for the LI spanned zero). Reasons for discrepancies between fMRI methods are discussed: one issue is that the toolbox method averages the LI across a wide range of thresholds. Furthermore, examination of task-related
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