Evidence map›Paper›PMID 38911357›Full record

ArticleCell reports. Physical science2024

Multifunctional hydrogels with spatially controlled light activation with photocaged oligonucleotides.

Katelyn Mathis, Saanvi Gaddam, Rishi Koneru, Nikhil Sunkavalli, Catherine Wang, Manan Patel, Afia Ibnat Kohon, Brian Meckes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Physical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katelyn MathisDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Saanvi GaddamDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Rishi KoneruDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Nikhil SunkavalliDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Catherine WangDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Manan PatelDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Afia Ibnat KohonDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.
Brian MeckesDepartment of Biomedical Engineering, University of North Texas, 3940 North Elm St., Denton, TX 76207, USA.

Funding

Mechanoregulators of Nanoparticle-Cell Interactions at Tissue InterfacesR35GM150577 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI Brian R Meckes · 2023 to 2026
$1.5M
Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable BondingR21GM141563 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI MECKES, BRIAN R · 2021 to 2022
$383k
NIGMS NIH HHS R21 GM141563NIGMS NIH HHS R35 GM150577
6 · The paper itself

Abstract

Recreating tissue environments with precise control over mechanical, biochemical, and cellular organization is essential for next-generation tissue models for drug discovery, development studies, and the replication of disease environments. However, controlling these properties at cell-scale lengths remains challenging. Here, we report the development of printing approaches that leverage polyethylene glycol diacrylate (PEGDA) hydrogels containing photocaged oligonucleotides to spatially program material characteristics with non-destructive, non-ultraviolet light. We further integrate this system with a perfusion chamber to allow us to alter the composition of PEGDA hydrogels while retaining common light-activatable photocaged DNAs. We demonstrate that the hydrogels can capture DNA functionalized materials, including cells coated with complementary oligonucleotides with spatial control using biocompatible wavelengths. Overall, these materials open pathways to orthogonal capture of any DNA functionalized materials while not changing the sequences of the DNA.

Identifiers

PMID38911357
PMCPMC11192495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.