ArticleEvolutionary applications2024
Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.
Article in Evolutionary applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Screening of Candidate SNPs Potentially Associated with Multi-Parity Litter Size and Litter Weight in Hu Sheep.Animals : an open access journal from MDPI · 2026Article
- Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits.Ecology and evolution · 2026Article
- Comparative Skin Transcriptome Analysis Identifies Candidate Genes Associated with Skin Responses in Hu Sheep Raised Under Different Regional Rearing Conditions.Animals : an open access journal from MDPI · 2026Article
- Genome-wide insights into genetic diversity and selection signatures during the formation of Yanyun sheep.BMC genomics · 2026Article
- Study on the Effect of N-Carbamylglutamate (NCG) on Reproductive Performance and Regulation Mechanism of Primary Lake Sheep.Animals : an open access journal from MDPI · 2026Article
- Runs of homozygosity reveal candidate genes for economic traits in Danish Large White pigs.Archives animal breeding · 2026Article
- Article
- Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes.Frontiers in veterinary science · 2026Article
- Composite selection signal analysis: Uncovering candidate genes and quantitative trait loci in Indian sheep breeds.PloS one · 2026Article
- Whole-genome variant of 220 Tibetan sheep from the Qinghai-Tibetan Plateau.Scientific data · 2025Article
- Genome-wide adaptive selection and functional annotation of regulatory variation in the Yangxin pig.BMC genomics · 2025Article
- Comparative detection of selection signatures in indigenous and crossbred Turkish sheep breeds.Scientific reports · 2025Article
- Study on the Genomic Basis of Adaptation in Salsk Sheep.Biology · 2025Article
- Impact of Heat Stress on Gene Expression in the Hypothalamic-Pituitary-Ovarian Axis of Hu Sheep.Animals : an open access journal from MDPI · 2025Article
- Article
- Whole-Genome Sequencing Reveals the Role of Cis-Regulatory Elements and eQTL/sQTL in the Adaptive Selection of Hubei Indigenous Cattle.Animals : an open access journal from MDPI · 2025Article
- Whole-Genome Resequencing in Sheep: Applications in Breeding, Evolution, and Conservation.Genes · 2025Review
- Identification and Analysis of InDel Variants in Key Hippo Pathway Genes and Their Association with Growth Traits in Four Chinese Sheep Breeds.Veterinary sciences · 2025Article
- Article
- Association ofGenes · 2025Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism of selection and further uncover the candidate genes associated with breed-specific traits subject to selection. Here, we conducted whole-genome resequencing on 206 Hu sheep individuals, each with an approximate 6-fold depth of coverage. And then we employed three complementary approaches, including composite likelihood ratio, integrated haplotype homozygosity score and the detection of runs of homozygosity, to detect selection signatures. In total, 10 candidate genomic regions displaying selection signatures were simultaneously identified by multiple methods, spanning 88.54 Mb. After annotating, these genomic regions harbored collectively 92 unique genes. Interestingly, 32 candidate genes associated with reproduction were distributed in nine genomic regions detected. Out of them, two stood out as star candidates:
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