Evidence map›Paper›PMID 38911165›Full record

ArticleRSC medicinal chemistry2024

Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents.

Zhen Wang, Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo, Yan Song, Yan Zou, Peichao Zhang, Guige Hou, Qingguo Meng and 2 more

Erratum issuedAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zhen WangSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University Yantai 264005 China qinggmeng@163.com.ORCID https://orcid.org/0000-0002-5754-2797
Juan ZhangSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University Yantai 264005 China qinggmeng@163.com.
Conghao GaiDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.ORCID https://orcid.org/0000-0001-6760-5045
Jing WangDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.
Xiaobin ZhuoDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.
Yan SongNavy Medical Center, Naval Medical University Shanghai 200433 China.
Yan ZouDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.
Peichao ZhangDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.
Guige HouSchool of Pharmacy, Binzhou Medical University Yantai 264003 China.ORCID https://orcid.org/0000-0002-9493-3981
Qingguo MengSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University Yantai 264005 China qinggmeng@163.com.
Qingjie ZhaoDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.
Xiaoyun ChaiDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University Shanghai 200433 China qjzhao_325@126.com chaixy1207@163.com.ORCID https://orcid.org/0000-0001-9688-9091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is the body's response to defence against infection or injury, and is associated with the progression of many diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA). LCA, a dibenzylbutane lignan extracted from the roots of traditional medicinal plant

Identifiers

PMID38911165
PMCPMC11187555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.