Evidence map›Paper›PMID 38911162›Full record

ArticleRSC medicinal chemistry2024

Deuterium labeling improves the therapeutic index of 3,3'-diselenodipropionic acid as an anticancer agent: insights from redox reactions.

V V Gandhi, M K Pal, B G Singh, R P Das, A P Wadawale, S Dey, A Kunwar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

V V GandhiRadiation and Photochemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India kamit@barc.gov.in 91 22 25505151 91 22 25592352/25595399.
M K PalChemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India dsandip@barc.gov.in 91 22 25592589.
B G SinghRadiation and Photochemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India kamit@barc.gov.in 91 22 25505151 91 22 25592352/25595399.ORCID https://orcid.org/0000-0002-1679-5456
R P DasRadiation and Photochemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India kamit@barc.gov.in 91 22 25505151 91 22 25592352/25595399.
A P WadawaleChemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India dsandip@barc.gov.in 91 22 25592589.
S DeyChemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India dsandip@barc.gov.in 91 22 25592589.ORCID https://orcid.org/0000-0001-9198-8808
A KunwarRadiation and Photochemistry Division, Bhabha Atomic Research Centre Mumbai - 400085 India kamit@barc.gov.in 91 22 25505151 91 22 25592352/25595399.ORCID https://orcid.org/0000-0003-1017-1527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3,3'-Diselenodipropionic acid (DSePA), a selenocystine derivative, has been previously reported as an oral supplement for anticancer/radio-modulation activities. The present study is focused on devising a strategy to synthesize and characterize the deuterated derivative of DSePA and on understanding the effect of deuteration on its therapeutic index by comparing its cytotoxicity in cancerous

Identifiers

PMID38911162
PMCPMC11187547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.