Evidence map›Paper›PMID 38911158›Full record

ArticleRSC medicinal chemistry2024

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents.

Mohammed Salah Ayoup, Mohamed Reda Barakat, Hamida Abdel-Hamid, Ehab Emam, Yasair S Al-Faiyz, Aliaa A Masoud, Doaa A Ghareeb, Amr Sonousi, Asmaa E Kassab

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Salah AyoupDepartment of Chemistry, College of Science, King Faisal University P.O. Box 400 Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa mohammedsalahayoup@gmail.com.ORCID https://orcid.org/0000-0001-6715-5478
Mohamed Reda BarakatChemistry Department, Faculty of Science, Alexandria University P.O. Box 426 Alexandria 21321 Egypt.
Hamida Abdel-HamidChemistry Department, Faculty of Science, Alexandria University P.O. Box 426 Alexandria 21321 Egypt.
Ehab EmamGeneral Q.C Manager, Alexandria company for pharmaceuticals Alexandria 21521 Egypt.
Yasair S Al-FaiyzDepartment of Chemistry, College of Science, King Faisal University P.O. Box 400 Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa mohammedsalahayoup@gmail.com.ORCID https://orcid.org/0000-0003-4755-613X
Aliaa A MasoudBio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University 21511 Alexandria Egypt.
Doaa A GhareebBio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University 21511 Alexandria Egypt.
Amr SonousiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University P.O. Box 11562, Kasr El-Aini Street Cairo Egypt asmaa.kassab@pharma.cu.edu.eg.
Asmaa E KassabDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University P.O. Box 11562, Kasr El-Aini Street Cairo Egypt asmaa.kassab@pharma.cu.edu.eg.ORCID https://orcid.org/0000-0002-6091-829X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their potential anti-Alzheimer disease activity. The results revealed that compounds 2b, 2c, 2d, 3a, 4a, 6, 9a, 9b, and 13b showed excellent inhibitory activity against acetylcholinesterase (AChE) with IC

Identifiers

PMID38911158
PMCPMC11187554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.