Evidence map›Paper›PMID 38911126›Full record

ArticleDevice2024

Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials.

Emily Witt, Alexander J Leach, Jianling Bi, Samual Hatfield, Alicia T Cotoia, Megan K McGovern, Arielle B Cafi, Ashley C Rhodes, Austin N Cook, Slyn Uaroon and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Device, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Gas entrapping materials for damage control.Advanced drug delivery reviews · 2026
    Review
  2. A smart CO-releasing MnSiOMaterials today. Bio · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Emily WittDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Alexander J LeachHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Jianling BiDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Samual HatfieldHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Alicia T CotoiaDepartment of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA.
Megan K McGovernDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Arielle B CafiDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Ashley C RhodesDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Austin N CookDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Slyn UaroonHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Bishal ParajuliDepartment of Pathology, University of Iowa, Iowa City, IA, 52242, USA.
Jinhee KimDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, ON M5S 1A8, Canada.
Vivian FeigDivision of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Alexandra ScheiflingerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Ikenna NwosuHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Miguel JimenezDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, ON M5S 1A8, Canada.
Mitchell C ColemanFree Radical and Radiation Biology Program, University of Iowa, Iowa City, IA, 52242, USA.
Marisa R BuchakjianHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Dustin E BoschHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Michael S TiftDepartment of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA.
Giovanni TraversoDivision of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Leo E OtterbeinDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
James D ByrneDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4M
Examining Carbon Monoxide to Treat Inflammatory Conditions using Experimental Colitis ModelsR01DK119202 · NIDDK · GEORGIA STATE UNIVERSITY · PI OTTERBEIN, LEO E, TAN, CHALET · 2019 to 2023
$3.6M
Early-Stage Preclinical Validation of Carbon Monoxide Prodrugs for Acute Kidney InjuryR01DK128823 · NIDDK · GEORGIA STATE UNIVERSITY · PI LEO E OTTERBEIN, Binghe Wang · 2022 to 2026
$3.5M
R25 YES: Cancer Research Opportunities at IowaR25CA273964 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman, Jessica C Sieren · 2023 to 2026
$1.4M
Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal BowelK08CA276908 · NCI · UNIVERSITY OF IOWA · PI James Donald Byrne · 2023 to 2026
$1.0M
Low Dose Oral Carbon Monoxide Therapeutic for Virus-Induced Lung InjuryR41AI164948 · NIAID · HILLHURST BIOPHARMACEUTICALS, INC. · PI GOMPERTS, EDWARD, OTTERBEIN, LEO E · 2022 to 2023
$600k
NCI NIH HHS K08 CA276908NCI NIH HHS L30 CA274783NCI NIH HHS P30 CA086862NCI NIH HHS R25 CA273964NIAID NIH HHS R41 AI164948NIDDK NIH HHS R01 DK119202NIDDK NIH HHS R01 DK128823NIGMS NIH HHS T32 GM139776
6 · The paper itself

Abstract

Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune modulating effects. To facilitate delivery of CO, we have designed hyaluronic acid-based CO-gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N

Identifiers

PMID38911126
PMCPMC11192243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.