Evidence map›Paper›PMID 38911025›Full record

ArticleFrontiers in cell and developmental biology2024

p38 MAPK as a gatekeeper of reprogramming in mouse migratory primordial germ cells.

Daiji Okamura, Aoi Kohara, Yuta Chigi, Tomoka Katayama, Jafar Sharif, Jun Wu, Yumi Ito-Matsuoka, Yasuhisa Matsui

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In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daiji Okamura *Department of Advanced Bioscience, Faculty of Agriculture, Kindai University, Nara, Japan.
Aoi Kohara *Department of Advanced Bioscience, Faculty of Agriculture, Kindai University, Nara, Japan.
Yuta Chigi *Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Tomoka KatayamaDepartment of Advanced Bioscience, Faculty of Agriculture, Kindai University, Nara, Japan.
Jafar SharifLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Jun WuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Yumi Ito-MatsuokaCell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Yasuhisa MatsuiCell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian germ cells are derived from primordial germ cells (PGCs) and ensure species continuity through generations. Unlike irreversible committed mature germ cells, migratory PGCs exhibit a latent pluripotency characterized by the ability to derive embryonic germ cells (EGCs) and form teratoma. Here, we show that inhibition of p38 mitogen-activated protein kinase (MAPK) by chemical compounds in mouse migratory PGCs enables derivation of chemically induced Embryonic Germ-like Cells (cEGLCs) that do not require conventional growth factors like LIF and FGF2/Activin-A, and possess unique naïve pluripotent-like characteristics with epiblast features and chimera formation potential. Furthermore, cEGLCs are regulated by a unique PI3K-Akt signaling pathway, distinct from conventional naïve pluripotent stem cells described previously. Consistent with this notion, we show by performing

Indexed as

EGCsgatekeepermigratory primordial germ cellsp38 MAPKpluripotencyreprogrammingteratoma

Identifiers

PMID38911025
PMCPMC11191381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.