Evidence map›Paper›PMID 38911024›Full record

ArticleAPL bioengineering2024

Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma.

Keith A Gagnon, Jessie Huang, Olivia T Hix, Veronica W Hui, Anne Hinds, Esther Bullitt, Jeroen Eyckmans, Darrell N Kotton, Christopher S Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keith A GagnonORCID https://orcid.org/0000-0002-8898-9372
Jessie HuangORCID https://orcid.org/0000-0002-5297-3563
Olivia T HixORCID https://orcid.org/0000-0001-8870-5571
Veronica W HuiDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.ORCID https://orcid.org/0009-0009-4459-3286
Anne HindsThe Pulmonary Center and Department of Medicine, Boston University Chobian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Esther BullittDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.ORCID https://orcid.org/0000-0003-2447-6209
Jeroen EyckmansORCID https://orcid.org/0000-0003-1475-8149
Darrell N KottonORCID https://orcid.org/0000-0002-9604-8476
Christopher S ChenORCID https://orcid.org/0000-0003-2445-8449

Funding

REGULATION OF ANGIOGENESIS BY MICROENVIRONMENTAL CUESR01EB000262 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2002 to 2023
$6.2M
Synthetic vascularization and regeneration in engineered tissuesR01EB033821 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SANGEETA N. BHATIA, CHRISTOPHER S CHEN · 2023 to 2026
$2.2M
NIBIB NIH HHS R01 EB000262
6 · The paper itself

Abstract

Previous lung-on-chip devices have facilitated significant advances in our understanding of lung biology and pathology. Here, we describe a novel lung-on-a-chip model in which human induced pluripotent stem cell-derived alveolar epithelial type II cells (iAT2s) form polarized duct-like lumens alongside engineered perfused vessels lined with human umbilical vein endothelium, all within a 3D, physiologically relevant microenvironment. Using this model, we investigated the morphologic and signaling consequences of the KRAS

Identifiers

PMID38911024
PMCPMC11191334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.