Evidence map›Paper›PMID 38910574›Full record

ArticleFuture medicinal chemistry2024

Design, synthesis and biological evaluation of 1-aryldonepezil analogues as anti-Alzheimer's disease agents.

Jiao Luo, Jing-Jing Xu, Hui-Jun Ren, Jin-Bu Xu, Feng Gao, Dong-Mei Fang, Lin-Xi Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiao LuoDepartment of Pharmacy, The Third People's Hospital of Chengdu, Chengdu, 610041, PR China.
Jing-Jing XuDepartment of Pharmacy, The Third People's Hospital of Chengdu, Chengdu, 610041, PR China.
Hui-Jun RenDepartment of Pharmacy, The Third People's Hospital of Chengdu, Chengdu, 610041, PR China.
Jin-Bu XuSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science & Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.
Feng GaoSichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science & Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.
Dong-Mei FangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, PR China.
Lin-Xi WanSichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China.

Funding

National Natural Science Foundation of China 82204244Natural Science Foundation of Sichuan Province 23NSFSC2370Young Pharmacist Foundation of Sichuan Hospital Association 22031
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetylcholinesteraseAlzheimer DiseaseButyrylcholinesteraseCholinesterase InhibitorsDrug DesignMolecular Docking SimulationNeuroprotective AgentsCell Line, TumorHumansHydrogen PeroxideIndolesMolecular StructurePiperidinesStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsHydrogen PeroxideIndolesN-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amineNeuroprotective AgentsPiperidinesAlzheimer's diseasecholinesterasedonepezil analoguesneuroprotective activityneurotoxicity

Identifiers

PMID38910574
PMCPMC11221548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.