ArticleeLife2024
Rapid bacterial evaluation beyond the colony forming unit in osteomyelitis.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Article
- Establishment of a human osteocyte model to reveal mechanisms of chronic Staphylococcus epidermidis bone and joint infections.Bone & joint research · 2026Article
- A bone histological approach to distinguish periprosthetic joint infection from aseptic osteolysis in revision joint replacement.Bone & joint research · 2026Article
- Accurate quantification of the bacterial inoculum and tissue load in a preclinical model of implant-related infection.Bone & joint research · 2026Article
- Murine Models of Klebsiella pneumoniae Gastrointestinal Infection.Current protocols · 2025Article
- Osteomyelitis-relevant antibiotics at clinical concentrations show limited effectivity against acute and chronic intracellularAntimicrobial agents and chemotherapy · 2024Article
- Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Examination of bacteria/host cell interactions is important for understanding the aetiology of many infectious diseases. The colony forming unit (CFU) has been the standard for quantifying bacterial burden for the past century, however, this suffers from low sensitivity and is dependent on bacterial culturability in vitro. Our data demonstrate the discrepancy between the CFU and bacterial genome copy number in an osteomyelitis-relevant co-culture system and we confirm diagnosis and quantify bacterial load in clinical bone specimens. This study provides an improved workflow for the quantification of bacterial burden in such cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.