Evidence map›Paper›PMID 38910439›Full record

ArticleJournal of dental research2024

Type VI Collagen Deficiency Causes Enhanced Periodontal Tissue Destruction.

T Komori, V Kram, S Perry, H T Pham, P Jani, T M Kilts, K Watanabe, D G Kim, D Martin, M F Young

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. An Implanted Tooth That Can Feel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

T KomoriMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
V KramMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
S PerryMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
H T PhamMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
P JaniMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
T M KiltsMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.
K WatanabeDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH, USA.
D G KimDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH, USA.
D MartinNIDCD/NIDCR Genomics and Computational Biology Core, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8880-9087
M F YoungMolecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA.

Funding

Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
INTEGRATIVE MECHANISMS OF CORTICAL NEURONSR01DC000086 · NIDCD · YALE UNIVERSITY · PI SHEPHERD, GORDON · 1989 to 2010
$3.6M
STRUCTURE AND BONE MATRIX GENE EXPRESSIONZ01DE000379 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI YOUNG, MARIAN F · 1985 to 2008
$2.5M
Intramural NIH HHS Z01 DE000379Intramural NIH HHS ZIC DC000086Intramural NIH HHS ZIC DE000750Intramural NIH HHS ZIG DE000740NIDCD NIH HHS R01 DC000086
6 · The paper itself

Abstract

The periodontal ligament (PDL) is a fibrillar connective tissue that lies between the alveolar bone and the tooth and is composed of highly specialized extracellular matrix (ECM) molecules and a heterogeneous population of cells that are responsible for collagen formation, immune response, bone formation, and chewing force sensation. Type VI collagen (COL6), a widely distributed ECM molecule, plays a critical role in the structural integrity and mechanical properties of various tissues including muscle, tendon, bone, cartilage, and skin. However, its role in the PDL remains largely unknown. Our study shows that deficiency of COL6 impairs PDL fibrillogenesis and exacerbates tissue destruction in ligature-induced periodontitis (LIP). We found that COL6-deficient mice exhibited increased bone loss and degraded PDL in LIP and that fibroblasts expressing high levels of

Indexed as

Collagen Type VIFibroblastsPeriodontal LigamentPeriodontitisAlveolar Bone LossAnimalsCell ProliferationDisease Models, AnimalExtracellular MatrixMiceMice, KnockoutCollagen Type VIbiomechanicsbone lossextracellular matrixinflammationperiodontal ligamentsingle-cell RNAseq

Identifiers

PMID38910439
PMCPMC11377870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.