Evidence map›Paper›PMID 38910391›Full record

ArticleJournal of dental research2024

Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'.

J O Piña, R Raju, D M Roth, E W Winchester, C Padilla, J Iben, F R Faucz, J L Cotney, R N D'Souza

Abstract read
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Genetic architecture of craniofacial morphogenesis: roles ofFrontiers in cell and developmental biology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

J O PiñaSection on Craniofacial Genetic Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3387-5770
R RajuSection on Craniofacial Genetic Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
D M RothSection on Craniofacial Genetic Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8156-4681
E W WinchesterUniversity of Connecticut School of Dental Medicine, Farmington, CT, USA.ORCID 0000-0003-2695-7938
C PadillaMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
J IbenMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
F R FauczMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
J L CotneyDepartment of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID 0000-0001-8230-2157
R N D'SouzaSection on Craniofacial Genetic Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1505-5173

Funding

Unraveling mechanisms of genome regulation to understand and improvehuman healthR35GM119465 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI COTNEY, JUSTIN LEE · 2016 to 2025
$3.9M
Functional characterization of craniofacial enhancers at single cell and single base pair resolutionR01DE028945 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI COTNEY, JUSTIN LEE · 2019 to 2023
$1.9M
Integrated multi-omics analyses of early mammalian craniofacial developmentR03DE028588 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI COTNEY, JUSTIN LEE · 2020 to 2021
$328k
Uncovering Caries Risk in the Noncoding Genome of the Developing ToothF30DE031149 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WINCHESTER, EMMA WENTWORTH · 2021 to 2023
$139k
Intramural NIH HHS ZIA HD009015NIDCR NIH HHS F30 DE031149NIDCR NIH HHS R01 DE028945NIDCR NIH HHS R03 DE028588NIGMS NIH HHS R35 GM119465
6 · The paper itself

Abstract

Multiple genetic and environmental etiologies contribute to the pathogenesis of cleft palate, which is the most common of the inherited disorders of the craniofacial complex. Insights into the molecular mechanisms regulating osteogenic differentiation and patterning in the palate during embryogenesis are limited and needed for the development of innovative diagnostics and cures. This study used the

Indexed as

Cleft PalateIntercellular Signaling Peptides and ProteinsOsteogenesisPalatePAX9 Transcription FactorWnt Signaling PathwayAnimalsCell DifferentiationDisease Models, AnimalMiceMice, KnockoutMultiomicsDkk2 protein, mouseIntercellular Signaling Peptides and ProteinsPax9 protein, mousePAX9 Transcription Factorcleft palatecraniofacial anomaliescraniofacial biology/geneticsgene expressionsignal transductionsingle-cell sequencing

Identifiers

PMID38910391
PMCPMC11653329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.