Evidence map›Paper›PMID 38910308›Full record

ArticleJournal of veterinary science2024

NOX4 and its association with myeloperoxidase and osteopontin in regulating endochondral ossification.

Kayoung Ko, Seohee Choi, Miri Jo, Chaeyoung Kim, Napissara Boonpraman, Jihyun Youm, Sun Shin Yi

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In one paragraph

Article in Journal of veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kayoung Ko *BK21 Four Project, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.ORCID https://orcid.org/0009-0004-4368-2600
Seohee Choi *BK21 Four Project, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.ORCID https://orcid.org/0009-0000-9963-4377
Miri JoBK21 Four Project, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.ORCID https://orcid.org/0009-0003-4698-2206
Chaeyoung KimBK21 Four Project, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.ORCID https://orcid.org/0009-0001-6008-0503
Napissara BoonpramanDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.ORCID https://orcid.org/0000-0002-8244-0530
Jihyun YoumDepartment of Gerontology, Graduate School of East-West Medical Science, Kyunghee University, Yongin 17104, Korea.ORCID https://orcid.org/0009-0003-2899-0149
Sun Shin YiBK21 Four Project, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.ORCID https://orcid.org/0000-0001-8568-0954

Funding

National Research Foundation of Korea NRF-2018R1D1A3B07047960Soonchunhyang University
6 · The paper itself

Abstract

importanceEndochondral ossification plays an important role in skeletal development. Recent studies have suggested a link between increased intracellular reactive oxygen species (ROS) and skeletal disorders. Moreover, previous studies have revealed that increasing the levels of myeloperoxidase (MPO) and osteopontin (OPN) while inhibiting NADPH oxidase 4 (NOX4) can enhance bone growth. This investigation provides further evidence by showing a direct link between NOX4 and MPO, OPN in bone function.

objectiveThis study investigates NOX4, an enzyme producing hydrogen peroxide, in endochondral ossification and bone remodeling. NOX4's role in osteoblast formation and osteogenic signaling pathways is explored.

methodsUsing NOX4-deficient (NOX4

resultsNOX4 CONCLUSIONS AND RELEVANCE: Our results emphasize NOX4's significance in bone morphology, mesenchymal stem cell proteomics, immunohistochemistry, collagen levels, and chondrogenesis. NOX4 deficiency enhances bone development and endochondral ossification, potentially through increased MPO, OPN, and COLII expression. These findings suggest therapeutic implications for skeletal disorders.

Indexed as

NADPH Oxidase 4OsteogenesisOsteopontinAnimalsCollagenFemaleMiceMice, Inbred C57BLMice, KnockoutOvariectomyPeroxidaseCollagenMpo protein, mouseNADPH Oxidase 4Nox4 protein, mouseOsteopontinPeroxidaseSpp1 protein, mouseEndochondral ossificationmyeloperoxidaseNADPH oxidase 4osteopontinovariectomy

Identifiers

PMID38910308
PMCPMC11291435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.