Evidence map›Paper›PMID 38910254›Full record

ArticleBMC genomics2024

Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium.

Paul B Stege, Dirkjan Schokker, Frank Harders, Soumya K Kar, Norbert Stockhofe, Vera Perricone, Johanna M J Rebel, Ingrid C de Jong, Alex Bossers

Abstract read
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul B StegeWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands. paul.stege@wur.nl.
Dirkjan SchokkerWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands.
Frank HardersWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands.
Soumya K KarWageningen Livestock Research, Wageningen University and Research, Wageningen, Netherlands.
Norbert StockhofeWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands.
Vera PerriconeDepartment of Veterinary Medicine and Animal Science, University of Milan, Milan, Italy.
Johanna M J RebelWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands.
Ingrid C de JongWageningen Livestock Research, Wageningen University and Research, Wageningen, Netherlands.
Alex BossersWageningen Bioveterinary Research, Wageningen University and Research, Lelystad, Netherlands.

Funding

Ministry of Agriculture, the Netherlands WOT-01-003-085/KB-37-003-013 Bioinformatics and sequencing applicationsWageningen University and Research 2019-2022 KB34 Towards a Circular and Climate Neutral Society
6 · The paper itself

Abstract

Modern broiler breeds allow for high feed efficiency and rapid growth, which come at a cost of increased susceptibility to pathogens and disease. Broiler growth rate, feed efficiency, and health are affected by the composition of the gut microbiota, which in turn is influenced by diet. In this study, we therefore assessed how diet composition can affect the broiler jejunal gut microbiota. A total of 96 broiler chickens were divided into four diet groups: control, coated butyrate supplementation, medium-chain fatty acid supplementation, or a high-fibre low-protein content. Diet groups were sub-divided into age groups (4, 12 and 33 days of age) resulting in groups of 8 broilers per diet per age. The jejunum content was used for metagenomic shotgun sequencing to determine the microbiota taxonomic composition at species level. The composed diets resulted in a total of 104 differentially abundant bacterial species. Most notably were the butyrate-induced changes in the jejunal microbiota of broilers 4 days post-hatch, resulting in the reduced relative abundance of mainly Enterococcus faecium (-1.8 l2fc, P

Indexed as

Animal FeedChickensEnterococcus faeciumEnterococcus hiraeGastrointestinal MicrobiomeJejunumAnimalsDietDietary SupplementsMetagenomicsButyrate supplementationDiet compositionMetagenomicsPoultry pathogens

Identifiers

PMID38910254
PMCPMC11193906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.