Evidence map›Paper›PMID 38910248›Full record

ReviewJournal of nanobiotechnology2024

Nanoscale insights into hematology: super-resolved imaging on blood cell structure, function, and pathology.

Jinghan Liu, Yuping Yolanda Tan, Wen Zheng, Yao Wang, Lining Arnold Ju, Qian Peter Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. 3D quantitative phase imagingRSC advances · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinghan LiuSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Yuping Yolanda TanCharles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
Wen ZhengSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Yao WangSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Lining Arnold JuSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Qian Peter SuSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia. qian.su@uts.edu.au.

Funding

National Health and Medical Research Council APP1177374National Health and Medical Research Council APP2003904
6 · The paper itself

Abstract

Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of biological samples at nanometric resolutions. A series of super-resolution techniques have been developed and applied to investigate the molecular distribution, organization, and interactions in blood cells, as well as the underlying mechanisms of blood-cell-associated diseases. In this review, we provide an overview of various fluorescence nanoscopy technologies, outlining their current development stage and the challenges they are facing in terms of functionality and practicality. We specifically explore how these innovations have propelled forward the analysis of thrombocytes (platelets), erythrocytes (red blood cells) and leukocytes (white blood cells), shedding light on the nanoscale arrangement of subcellular components and molecular interactions. We spotlight novel biomarkers uncovered by fluorescence nanoscopy for disease diagnosis, such as thrombocytopathies, malignancies, and infectious diseases. Furthermore, we discuss the technological hurdles and chart out prospective avenues for future research directions. This review aims to underscore the significant contributions of fluorescence nanoscopy to the field of blood cell analysis and disease diagnosis, poised to revolutionize our approach to exploring, understanding, and managing disease at the molecular level.

Indexed as

Blood CellsMicroscopy, FluorescenceAnimalsBlood PlateletsErythrocytesHematologyHumansLeukocytesNanotechnologyBlood cellsBlood diseasesFluorescence nanoscopyPlateletsRed blood cellsSuper-resolution microscopyWhite blood cells

Identifiers

PMID38910248
PMCPMC11194919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.