Evidence map›Paper›PMID 38910194›Full record

ArticleJournal of gastrointestinal cancer2024

Expression of Interleukin-8, Interleukin-12 and Interleukin-13 in Esophageal Squamous Cell Carcinoma: Biomarker Potentiality and Prognostic Significance.

Jayasree Talukdar, Abdul Malik, Kangkana Kataki, Bikash Narayan Choudhury, Munindra Narayan Baruah, Mallika Bhattacharyya, Manash Pratim Sarma, Minakshi Bhattacharjee, Mrinmoy Basak, Manash Pratim Kashyap and 12 more

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Interleukin-8 in health and disease.Molecular biomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jayasree Talukdar *Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Abdul Malik *Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Kangkana KatakiDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Bikash Narayan ChoudhuryDepartment of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India.
Munindra Narayan BaruahDepartment of Head and Neck Oncology, North East Cancer Hospital and Research Institute, Jorabat, Assam, India.
Mallika BhattacharyyaDepartment of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India.
Manash Pratim SarmaProgram of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India.
Minakshi BhattacharjeeProgram of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India.
Mrinmoy BasakFaculty of Pharmaceutical Sciences, Assam down town University, Guwahati, Assam, India.
Manash Pratim KashyapProgram of Statistics, Faculty of Science, Assam down town University, Guwahati, Assam, India.
Sahana BhattacharjeeDepartment of Statistics, Gauhati University, Gawahati, Assam, India.
Eyashin AliDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Chenole KeppenDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Simanta KalitaDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Manash Jyoti KalitaDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Partha Pratim DasMultidisciplinary Research Unit, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, India.
Gautam HazarikaDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Ankur Jyoti DekaDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Kalpajit DuttaDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Mohammad Ghaznavi IdrisDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.
Suhail AkhtarA. T. Still University of Health Sciences, Kirksville, MO, USA.
Subhash MedhiDepartment of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India. subhashmedhi@gauhati.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInterleukin-8 (IL8), Interleukin-12 (IL12) and Interleukin-13 (IL13) are cytokines that play regulatory role in cancer pathogenesis. We analysed their expression profile to evaluate as molecular biomarkers of esophageal squamous cell carcinoma (ESCC) and their association with different parameters and patient survival.

methodsExpression analysis was performed by Real time quantitative polymerase chain reaction and receiver operating characteristic (ROC) curve analysis was done. The expression profiles were associated with different clinicopathological and dietary factors. Survival and hazard analysis were also performed.

resultsIL8 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.481), IL12 expression showed downregulation in tissue samples (p = 0.064) and upregulation in blood samples (p = 0.689) and IL13 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.006). IL13 expression in tissue showed the highest area under the curve (AUC) value (0.773) for ESCC diagnosis, followed by IL8 expression in tissue (0.704) and IL13 expression in blood (0.643). This study also reveals the correlation of studied cytokines in tissue and blood level. Different clinicopathological and dietary factors showed significant association (p < 0.05) with IL8, IL12 and IL13 expression and with survival of ESCC patients. IL8 expression in blood and IL12 expression in tissue and blood showed significant association (p < 0.05) with patient survival.

conclusionAltered expression of IL8, IL12 and IL13 may be associated with ESCC progression. Overexpression of IL8 and IL13 in tissue samples may be potential biomarkers for ESCC screening. Additionally, both survival and hazard analysis data indicate the effects of different parameters on the prognosis of ESCC patients.

Indexed as

Biomarkers, TumorEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaInterleukin-12Interleukin-13Interleukin-8AgedCarcinoma, Squamous CellFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorCXCL8 protein, humanIL13 protein, humanInterleukin-12Interleukin-13Interleukin-8Dietary habitsEsophageal squamous cell carcinomaInterleukin-12Interleukin-13Interleukin-8Survival analysis

Identifiers

PMID38910194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.