Evidence map›Paper›PMID 38910168›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024

Causal relationship between basal metabolic rate and intervertebral disc degeneration: a Mendelian randomization study.

Zhengqiang Liu, Huili Cai, Zhenyu Zhou, Shiwen Chen, Diao Yang, Can Zhuo, Haidan Chen

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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengqiang Liu *Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.
Huili Cai *Department of Hematology, The First College of Clinical Medical Science China Three Gorges University, China Three Gorges University, Yichang, Hubei, 443003, China.
Zhenyu ZhouDepartment of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.
Shiwen ChenDepartment of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.
Diao YangDepartment of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.
Can ZhuoDepartment of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.
Haidan ChenDepartment of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China. wenquanchd@sina.com.

Funding

Natural Science Foundation of Hubei Province 2016CFB600
6 · The paper itself

Abstract

backgroundThe role of basal metabolic rate (BMR) in intervertebral disc degeneration (IVDD) is still uncertain. To address this gap, we conducted a Mendelian randomization (MR) study to comprehensively explore the causal relationship between BMR and IVDD.

methodsBMR data were obtained from a large genome-wide association study (GWAS) database, while IVDD data were derived from the FinnGen project. The causal relationship between IVDD and BMR was investigated using MR, with inverse-variance weighting (IVW) as the primary estimate. MR-Egger weighed median and weighed mode were employed for robustness. Sensitivity analyses, including the Cochran Q test, leave-one-out analysis, and MR-Egger intercept analysis, were conducted. Furthermore, the study also identified causal relationships between IVDD and factors associated with BMR (hyperthyroidism, type 2 diabetes, standing height, weight, and body mass index). Multivariable MR was applied to further assess the direct effect of BMR on IVDD.

resultsGenetic predisposition to BMR (after removing outliers OR: 1.49; 95% CI: 1.37-1.63; P = 5.073e-21) were associated with an increased risk of IVDD. Additionally, IVDD risk increased with greater height, weight, and BMI. No causal relationship was observed between hy/thy and T2D and intervertebral disc degeneration (IVDD) (P > 0.05). In multivariable MR, a significant causal association between BMR and IVDD persisted, even after adjusting for BMI, height, and weight.

conclusionIn this study, we successfully identified that a higher BMR is independently and causally linked to IVDD, indicating an increased risk of developing IVDD. These findings suggest that managing BMR could potentially mitigate the risk of IVDD.

Indexed as

Basal MetabolismGenome-Wide Association StudyIntervertebral Disc DegenerationMendelian Randomization AnalysisFemaleGenetic Predisposition to DiseaseHumansMaleBasal metabolic rateGenome-wide association studyIntervertebral disc degenerationMendelian randomization

Identifiers

PMID38910168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.