ArticleJournal of atherosclerosis and thrombosis2024
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.
Article in Journal of atherosclerosis and thrombosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Quantifying the utility of type 2 diabetes polygenic risk score for predicting incident diabetes: an analysis of large US-based cohort studies.BMC medical genomics · 2026Article
- Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization.Circulation reports · 2026Article
- Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk.Clinical kidney journal · 2025Article
- Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The Role of Polygenic Risk Score in the General Population: Current Status and Future Prospects.Journal of atherosclerosis and thrombosis · 2025Review
- Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study.Cardiovascular diabetology · 2025Article
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Authors and funding
32 authors.
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Abstract
aimThis study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes.
methodsThis prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC).
resultOf the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]).
conclusionOur findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
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