Evidence map›Paper›PMID 38909975›Full record

ArticleMethods (San Diego, Calif.)2024

A comprehensive preanalytical protocol for fresh solid tumor biospecimens.

Areesha A Charania, Aman G Pokal, Dana R Zuaiter, Chelsea L Crawford, Ashwini K Esnakula, Mozaffarul Islam, Alex C Kim, Karim I Budhwani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods (San Diego, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Areesha A CharaniaCerFlux, Birmingham, AL, USA.
Aman G PokalCerFlux, Birmingham, AL, USA.
Dana R ZuaiterCerFlux, Birmingham, AL, USA.
Chelsea L CrawfordCerFlux, Birmingham, AL, USA.
Ashwini K EsnakulaThe Ohio State University Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
Mozaffarul IslamThe Ohio State University Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
Alex C KimThe Ohio State University Wexner Medical Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
Karim I BudhwaniCerFlux, Birmingham, AL, USA. Electronic address: IronMan@CerFlux.com.

Funding

Development of personalized ex vivo predictive technology for rapidly matching patient tumors with chemotherapy regimens before treatment.R43CA254493 · NCI · CERFLUX, INC. · PI BUDHWANI, KARIM I · 2020 to 2021
$301k
NCI NIH HHS R43 CA254493
6 · The paper itself

Abstract

Nearly seventy percent of diagnostic lab test errors occur due to variability in preanalytical factors. These are the parameters involved with all aspects of tissue processing, starting from the time tissue is collected from the patient in the operating room, until it is received and tested in the laboratory. While there are several protocols for transporting fixed tissue, organs, and liquid biopsies, such protocols are lacking for transport and handling of live solid tumor tissue specimens. There is a critical need to establish preanalytical protocols to reduce variability in biospecimen integrity and improve diagnostics for personalized medicine. Here, we provide a comprehensive protocol for the standard collection, handling, packaging, cold-chain logistics, and receipt of solid tumor tissue biospecimens to preserve tissue viability.

Indexed as

NeoplasmsSpecimen HandlingHumansPrecision MedicineBiospecimen integrityBiotechnologyCancerLab developed testPathologyPreanalytical variabilityTissue viability

Identifiers

PMID38909975
PMCPMC11296924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.