ArticleNeurobiology of aging2024
The relationship between cortical thickness and white matter hyperintensities in mid to late life.
Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Growth of White Matter Signal Aberrations and Cortical Changes in Men and Women: A 9-Year Multiple-Time-Point Longitudinal MRI Study in Older Adults.Human brain mapping · 2026Article
- MIND diet moderates the associations between cerebrovascular and neurodegenerative disease burden and cognition.Frontiers in nutrition · 2026Article
- Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults.Neurobiology of aging · 2025Article
- Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health.Communications medicine · 2025Article
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Authors and funding
4 authors.
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Abstract
White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26-50 years) and relatively older (58-84) participants who were free of dementia, and how these associations are moderated by WMH localization. WMH were automatically quantified and categorized according to the localization of three classes of white matter tracts: association, commissural and projection fibers. Mediation analyses were used to infer whether differences in cortical thickness between younger and older participants were explained by WMH. Our results revealed that total WMH explained between 20.6 % and 65.5 % of the effect of age on cortical thickness in AD-signature regions including the lateral temporal lobes and supramarginal gyrus, among others. This mediation was slightly stronger for projection WMH, although it was still significant for association and commissural WMH. These results suggest that there is an interplay between vascular and AD causes of cognitive impairment that starts at younger ages.
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