Evidence map›Paper›PMID 38909225›Full record

ArticleBMC complementary medicine and therapies2024

Toxicity assessment of Cucurbita pepo cv Dayangua and its effects on gut microbiota in mice.

Huan Zhang, Yazhou Zhou, Zhiyuan Pan, Bikun Wang, Lei Yang, Nan Zhang, Baiyi Chen, Xiaona Wang, Zhiguang Jian, Likun Wang and 8 more

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In one paragraph

Article in BMC complementary medicine and therapies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Huan Zhang *School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.
Yazhou Zhou *State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Zhiyuan PanState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Bikun WangState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Lei YangSchool of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.
Nan ZhangHeilongjiang Biodi Bio-Pharma Technology Company Lmt., No. 178, Yuexiujie, Harbin, Heilongjiang Province, China.
Baiyi ChenHeilongjiang Biodi Bio-Pharma Technology Company Lmt., No. 178, Yuexiujie, Harbin, Heilongjiang Province, China.
Xiaona WangHeilongjiang Biodi Bio-Pharma Technology Company Lmt., No. 178, Yuexiujie, Harbin, Heilongjiang Province, China.
Zhiguang JianHeilongjiang Biodi Bio-Pharma Technology Company Lmt., No. 178, Yuexiujie, Harbin, Heilongjiang Province, China.
Likun WangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Hui LingState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Xiaoming QinState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Zhelin ZhangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
Teng LiuSchool of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.
Aiping ZhengState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Yafang TanState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China. tanyafang@sina.com.
Yujing BiState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China. byj7801@sina.com.
Ruifu YangSchool of Public Health, Hebei Medical University, Shijiazhuang, 050017, China. ruifuyang@gmail.com.

Funding

National Key Research and Development Program of China 2021YFC2301000National Natural Science Foundation of China 32394054 and 31970863
6 · The paper itself

Abstract

backgroundCucurbita pepo cv Dayangua (CPD) is an edible plant with diverse pharmacological properties. The current research on CPD has primarily focused on initial investigations of its chemical composition and pharmacological effects, and no comprehensive toxicity assessment has been conducted to date.

methodsIn the present study, the toxicity of CPD was evaluated through both acute and sub-chronic oral toxicity tests in mice. 16S rDNA sequencing was used to analyze the composition of the gut microbiota of mice at different time points to observe the effect of CPD on these microbial communities.

resultsIn the acute toxicity test, CPD exhibited low toxicity, with a median lethal dose (LD50) > 2000 mg/kg. The sub-chronic toxicity test indicated that CPD administration at doses of 200, 400, and 600 mg/kg did not cause mortality or significant organ damage in mice. Furthermore, analysis of the gut microbiota after gavage administration of CPD at 400 and 600 mg/kg revealed an improved abundance of some beneficial gut bacteria.

conclusionsIn summary, no acute or sub-chronic toxic effects were observed in mice following the oral administration of CPD. CPD did not affect the structure and diversity of the gut microbiota and may contribute to an increase in the number of beneficial gut bacteria.

Indexed as

CucurbitaGastrointestinal MicrobiomeAnimalsFemaleMaleMicePlant ExtractsToxicity Tests, AcutePlant ExtractsAcute toxicityCucurbita pepo cv DayanguaGut microbiotaSub-chronic toxicity

Identifiers

PMID38909225
PMCPMC11193904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.