Evidence map›Paper›PMID 38909172›Full record

ArticleEuropean journal of clinical nutrition2024

Iron incorporation in red blood cells of pediatric sickle cell anemia: a stable isotope pilot investigation.

Juliana Omena, Vanessa Monteiro Voll, Flávia Fioruci Bezerra, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Carmen Marino Donangelo, Gustavo Federico Jauregui, Andrea Soares Ribeiro, Cláudia Dos Santos Cople Rodrigues, Marta Citelli

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Article in European journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliana Omena *Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil. omenaju@gmail.com.
Vanessa Monteiro Voll *Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Flávia Fioruci BezerraNutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Bernardo Ferreira BrazInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ricardo Erthal SantelliInstitute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-9812-6098
Carmen Marino DonangeloSchool of Nutrition, University of the Republic, Montevideo, Uruguay.
Gustavo Federico JaureguiRadiology Department, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.
Andrea Soares RibeiroHematology Department, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.
Cláudia Dos Santos Cople RodriguesNutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Marta CitelliNutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil. martacitelli@gmail.com.ORCID http://orcid.org/0000-0003-1380-3729

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brazilian Federal Agency for the Support and Evaluation of Graduate Education) 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro) E-26-010.100930/2018 and E-26/200.963/2022
6 · The paper itself

Abstract

BACKGROUND/

objectivesSickle cell anemia (SCA) is marked by hypoxia, inflammation, and secondary iron overload (IO), which potentially modulate hepcidin, the pivotal hormone governing iron homeostasis. The aim was to evaluate the iron incorporation in red blood cells (RBC) in SCA pediatric patients, considering the presence or absence of IO. SUBJECTS/

methodsSCA children (n = 12; SCA

resultsThe SCAio+ group had lower iron incorporation (mean ± SD: 0.166 ± 0.04 mg; 3.33 ± 0.757%) than SCAio- patients (0.746 ± 0.303 mg; 14.9 ± 6.05%) (p = 0.024). Hepcidin was not different between groups. Iron incorporation was inversely associated with serum ferritin level (SCA

conclusionSCAio+ group had lower iron incorporation in RBC than SCAio- group, suggesting that they may not need to reduce their intake of iron-rich food, as usually recommended. Conversely, a high percentage of HbS may indirectly exacerbate hypoxia and seems to increase iron incorporation in RBC.

trial registrationThis trial was registered at www.ensaiosclinicos.gov.br . Identifier RBR-4b7v8pt.

Indexed as

Anemia, Sickle CellErythrocytesFerritinsHepcidinsIronIron IsotopesIron OverloadAdolescentChildFemaleHumansLiverMalePilot ProjectsFerritinsHepcidinsIronIron Isotopes

Identifiers

PMID38909172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.