ArticleScientific reports2024
First-night effect reduces the beneficial effects of sleep on visual plasticity and modifies the underlying neurochemical processes.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Unconscious switching of dorsal and medial pathways for plasticity and stability during NREM and REM sleep.bioRxiv : the preprint server for biology · 2025Article
- Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Detection and Severity Classification of Sleep Apnea Using Continuous Wearable SpOSensors (Basel, Switzerland) · 2025Article
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Abstract
Individuals experience difficulty falling asleep in a new environment, termed the first night effect (FNE). However, the impact of the FNE on sleep-induced brain plasticity remains unclear. Here, using a within-subject design, we found that the FNE significantly reduces visual plasticity during sleep in young adults. Sleep-onset latency (SOL), an indicator of the FNE, was significantly longer during the first sleep session than the second session, confirming the FNE. We assessed performance gains in visual perceptual learning after sleep and increases in the excitatory-to-inhibitory neurotransmitter (E/I) ratio in early visual areas during sleep using magnetic resonance spectroscopy and polysomnography. These parameters were significantly smaller in sleep with the FNE than in sleep without the FNE; however, these parameters were not correlated with SOL. These results suggest that while the neural mechanisms of the FNE and brain plasticity are independent, sleep disturbances temporarily block the neurochemical process fundamental for brain plasticity.
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