Evidence map›Paper›PMID 38909092›Full record

ArticleThe international journal of cardiovascular imaging2024

Subclinical association of aortic stiffness with cardiac structure and function in African-Americans: The Jackson Heart Study.

Mawra Jha, Solomon Musani, Inbar McCarthy, W Gregory Hundley, John Jeffrey Carr, James G Terry, Adebamike Oshunbade, Ramachandran S Vasan, Javed Butler, Michael Hall and 3 more

Abstract read
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In one paragraph

Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mawra JhaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RW-453, Boston, MA, 02215, USA.
Solomon MusaniDivision of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Inbar McCarthyLahey Hospital & Medical Center, Jackson, MA, USA.
W Gregory HundleyPauley Heart Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
John Jeffrey CarrDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
James G TerryPauley Heart Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Adebamike OshunbadeDivision of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Ramachandran S VasanSections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Department of Epidemiology, Boston University School of Medicine, Boston University School of Public Health, Boston, MA, USA.
Javed ButlerDivision of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Michael HallDivision of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Gary F MitchellCardiovascular Engineering Inc, Norwood, MA, USA.
Ervin FoxDivision of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Connie W TsaoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RW-453, Boston, MA, 02215, USA. ctsao1@bidmc.harvard.edu.

Funding

Mechanistic Determinants of Healthy and Unhealthy Cardiovascular AgingR03HL145195 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSAO, CONNIE · 2018 to 2019
$175k
NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INIH HHS NIH R03 HL145195NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

Cardiovascular disease (CVD) morbidity and mortality are high among black adults. We aimed to study the granular subclinical relations of aortic stiffness and left ventricular (LV) function and remodeling in blacks, in whom limited data are available. In the Jackson Heart Study, 1050 U.S. community-dwelling black adults without CVD underwent 1.5 T cardiovascular magnetic resonance. We assessed regional and global aortic stiffness and LV structure and function, including LV mass indexed to body surface area (LVMI), end-diastolic volume (LVEDV), ejection fraction (EF), and global and regional circumferential strain (Ecc). Phase contrast images of the cross-sectional aorta at the pulmonary artery bifurcation and abdominal aorta bifurcation were acquired to measure pulse wave velocity of the aortic arch (AA-PWV) and thoracic aorta (T-PWV). Results of multivariable-adjusted analyses are presented as SD unit change in LV variables per SD change in PWV variables. Participants were 62% women with mean age of 59 ± 10 years. Higher AA-PWV and T-PWV were associated with greater LVMI: for T-PWV, β = 0.10, 95% CI = 0.03-0.16, p = 0.002. Higher AA-PWV and T-PWV were associated with worse (more positive) Ecc at the LV base (for AA-PWV, β = 0.13, 95% CI = 0.05-0.20, p = 0.0007), but not mid-LV or apex. AA-PWV and T-PWV were not associated with LV mass/LVEDV or EF. In this cross-sectional study of blacks without CVD in the U.S., aortic stiffness is associated with subclinical adverse LV function in basal segments. Future studies may elucidate the temporal relationships of aortic stiffness on the pattern and progression of LV remodeling, dysfunction, and associated prognosis in blacks.

Indexed as

Asymptomatic DiseasesBlack or African AmericanPulse Wave AnalysisVascular StiffnessVentricular Function, LeftVentricular RemodelingAdultAgedCross-Sectional StudiesFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMississippiPredictive Value of TestsAortic stiffnessCardiovascular magnetic resonanceLeft ventriclePulse wave velocityStrain

Identifiers

PMID38909092

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.