Evidence map›Paper›PMID 38908736›Full record

ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2024

Strategies of rational and structure-driven vaccine design for Arenaviruses.

Antonia Sophia Peter, Dieter S Hoffmann, Johannes Klier, Christina M Lange, Johanna Moeller, Victoria Most, Christina K Wüst, Max Beining, Sevilay Gülesen, Hannes Junker and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antonia Sophia PeterInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Dieter S HoffmannInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Johannes KlierInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Christina M LangeInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Johanna MoellerInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany.
Victoria MostInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Christina K WüstInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; Molecular Medicine Studies, Faculty for Biology and Preclinical Medicine, University of Regensburg, Regensburg, Germany.
Max BeiningInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; SECAI, School of Embedded Composite Artificial Intelligence, Dresden/Leipzig, Germany.
Sevilay GülesenInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Hannes JunkerInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Birke BrummeInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany.
Torben SchiffnerInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; The Scripps Research Institute, Department for Immunology and Microbiology, La Jolla, CA, United States.
Jens MeilerInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany; Department of Chemistry, Vanderbilt University, Nashville, TN, United States; Center for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Clara T SchoederInstitute for Drug Discovery, Leipzig University, Faculty of Medicine, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany. Electronic address: clara.schoeder@medizin.uni-leipzig.de.

Funding

Structure based design of trimer interface epitope focused universal influenza vaccinesU01AI150739 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E · 2020 to 2024
$6.1M
GPU-Accelerated Parallel Computer for Life Sciences ResearchS10OD032234 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2022 to 2022
$600k
Parallel Computer with High Memory NodesS10OD016216 · OD · VANDERBILT UNIVERSITY · PI PISTON, DAVID W · 2013 to 2013
$598k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NIAID NIH HHS U01 AI150739NIH HHS S10 OD016216NIH HHS S10 OD020154NIH HHS S10 OD032234
6 · The paper itself

Abstract

The COVID-19 outbreak has highlighted the importance of pandemic preparedness for the prevention of future health crises. One virus family with high pandemic potential are Arenaviruses, which have been detected almost worldwide, particularly in Africa and the Americas. These viruses are highly understudied and many questions regarding their structure, replication and tropism remain unanswered, making the design of an efficacious and molecularly-defined vaccine challenging. We propose that structure-driven computational vaccine design will contribute to overcome these challenges. Computational methods for stabilization of viral glycoproteins or epitope focusing have made progress during the last decades and particularly during the COVID-19 pandemic, and have proven useful for rational vaccine design and the establishment of novel diagnostic tools. In this review, we summarize gaps in our understanding of Arenavirus molecular biology, highlight challenges in vaccine design and discuss how structure-driven and computationally informed strategies will aid in overcoming these obstacles.

Indexed as

ArenavirusViral VaccinesAnimalsArenaviridae InfectionsCOVID-19EpitopesHumansSARS-CoV-2Vaccine DevelopmentEpitopesViral VaccinesArenavirusComputational vaccine designLassa virusMammarenavirusVaccine

Identifiers

PMID38908736
PMCPMC12010953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.