Evidence map›Paper›PMID 38908438›Full record

ArticleNeurotoxicology2024

Childhood exposure to organophosphate pesticides: Functional connectivity and working memory in adolescents.

Yuanyuan Gao, Rihui Li, Qianheng Ma, Joseph M Baker, Stephen Rauch, Robert B Gunier, Ana M Mora, Katherine Kogut, Asa Bradman, Brenda Eskenazi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuanyuan GaoCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, United States. Electronic address: yuanygao@stanford.edu.
Rihui LiCenter for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macau; Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau.
Qianheng MaCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, United States.
Joseph M BakerCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, United States.
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.
Ana M MoraCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.
Katherine KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.
Asa BradmanCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States; Department of Public Health, University of California, Merced, CA, United States.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, United States; Department of Radiology, School of Medicine, Stanford University, Stanford, CA, United States; Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States.
Sharon K SagivCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, United States.

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
TRAINING FOR CHILD PSYCHIATRY AND CHILD DEVELOPMENTT32MH019908 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB, DAVID S HONG · 1993 to 2026
$6.3M
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohortUG3OD023356 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2017
$2.6M
PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenR01ES015572 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2007 to 2010
$2.0M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Early life exposure to agricultural pesticides and functional brain imaging in young adultsR21ES032592 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI REISS, ALLAN L, SAGIV, SHARON K. · 2021 to 2022
$453k
Investigation of the role of Turner syndrome on approximate number senseK99HD092883 · NICHD · STANFORD UNIVERSITY · PI BAKER, JOSEPH · 2018 to 2020
$327k
NICHD NIH HHS K99 HD092883NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES015572NIEHS NIH HHS R21 ES032592NIEHS NIH HHS U24 ES028529NIH HHS UG3 OD023356NIMH NIH HHS T32 MH019908
6 · The paper itself

Abstract

backgroundEarly life exposure to organophosphate (OP) pesticides is linked with adverse neurodevelopment and brain function in children. However, we have limited knowledge of how these exposures affect functional connectivity, a measure of interaction between brain regions. To address this gap, we examined the association between early life OP pesticide exposure and functional connectivity in adolescents.

methodsWe administered functional near-infrared spectroscopy (fNIRS) to 291 young adults with measured prenatal or childhood dialkylphosphates (DAPs) in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a longitudinal study of women recruited during pregnancy and their offspring. We measured DAPs in urinary samples collected from mothers during pregnancy (13 and 26 weeks) and children in early life (ages 6 months, 1, 2, 3, and 5 years). Youth underwent fNIRS while they performed executive function and semantic language tasks during their 18-year-old visit. We used covariate-adjusted regression models to estimate the associations of prenatal and childhood DAPs with functional connectivity between the frontal, temporal, and parietal regions, and a mediation model to examine the role of functional connectivity in the relationship between DAPs and task performance.

resultsWe observed null associations of prenatal and childhood DAP concentrations and functional connectivity for the entire sample. However, when we looked for sex differences, we observed an association between childhood DAPs and functional connectivity for the right interior frontal and premotor cortex after correcting for the false discovery rate, among males, but not females. In addition, functional connectivity appeared to mediate an inverse association between DAPs and working memory accuracy among males.

conclusionIn CHAMACOS, a secondary analysis showed that adolescent males with elevated childhood OP pesticide exposure may have altered brain regional connectivity. This altered neurofunctional pattern in males may partially mediate working memory impairment associated with childhood DAP exposure.

Indexed as

Memory, Short-TermPesticidesPrenatal Exposure Delayed EffectsAdolescentBrainChild, PreschoolEnvironmental ExposureFemaleHumansInfantLongitudinal StudiesMaleOrganophosphatesOrganophosphorus CompoundsPregnancySpectroscopy, Near-InfraredOrganophosphatesOrganophosphorus CompoundsPesticidesDialkyl phosphatesFunctional connectivityMexicanNeurodevelopmentOrganophosphatesPrenatal

Identifiers

PMID38908438
PMCPMC11302996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.