Evidence map›Paper›PMID 38908063›Full record

ArticleCell calcium2024

Loss-of-function W4645R mutation in the RyR2-caffeine binding site: implications for synchrony and arrhythmogenesis.

José-Carlos Fernández-Morales, Noemi Toth, Pinar Bayram, Taylor Rienzo, Martin Morad

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Characterization of cardiac disease-associated mutations in RyR2 CaAmerican journal of physiology. Cell physiology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

José-Carlos Fernández-MoralesCardiac Signaling Center of MUSC, USC and Clemson University, Charleston, SC, USA.
Noemi TothCardiac Signaling Center of MUSC, USC and Clemson University, Charleston, SC, USA.
Pinar BayramCardiac Signaling Center of MUSC, USC and Clemson University, Charleston, SC, USA.
Taylor RienzoCardiac Signaling Center of MUSC, USC and Clemson University, Charleston, SC, USA.
Martin MoradCardiac Signaling Center of MUSC, USC and Clemson University, Charleston, SC, USA; Department of Regenerative Medicine and Cell Biology, MUSC,Charleston, SC, USA. Electronic address: moradm@musc.edu.

Funding

Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesR01HL153504 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2021 to 2024
$2.0M
Functional implications of RyR2 mutations in human cardiomyocytesR56HL147054 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2019 to 2019
$607k
NHLBI NIH HHS R01 HL153504NHLBI NIH HHS R56 HL147054
6 · The paper itself

Abstract

aimsPrevious studies have identified RyR2 W4645R mutation, located in the caffeine-binding site, to associate with CPVT1 pathology. Caffeine binding to its site is thought to displace the carboxyl-terminal domain to Ca METHODS AND

resultsW4645R-RyR2 cardiomyocytes had: (1) no significant change in I

conclusionsW4645R-RyR2 mutation induces loss of caffeine-triggered SR Ca

Indexed as

CaffeineInduced Pluripotent Stem CellsMyocytes, CardiacRyanodine Receptor Calcium Release ChannelArrhythmias, CardiacBinding SitesCalciumCalcium SignalingHumansLoss of Function MutationCaffeineCalciumRyanodine Receptor Calcium Release ChannelRyR2 protein, humanCaffeine-binding siteCPVT1Crispr/cas9human induced Pluripotent Stem CellsRyanodine receptor mutation

Identifiers

PMID38908063
PMCPMC11392648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.