ArticleNucleic acids research2024
A treasure trove of 1034 actinomycete genomes.
Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genome sequences of sevenMicrobiology resource announcements · 2026Article
- Heterologous production of a plant biostimulant in Streptomyces albidoflavus.Applied microbiology and biotechnology · 2026Article
- Barbell reveals and resolves demultiplexing and trimming issues in Nanopore data.Bioinformatics (Oxford, England) · 2026Article
- Evidence supporting the first secondary chromosome in Actinobacteria as a hallmark of theMicrobial genomics · 2026Article
- Article
- Unraveling rare codon bias in Actinomycetota: lineage-specific and 5' terminal enrichment across 1936 genomes.BMC genomics · 2026Article
- A histidine pseudokinase modulates polar growth and cell shape in Streptomyces venezuelae.Communications biology · 2026Article
- Stage-associated enrichment ofFrontiers in veterinary science · 2026Article
- A Rapid and Cost-Effective Pipeline to Identify and Capture BGCs From Bacterial Draft Genomes.Bio-protocol · 2025Article
- Genome sequence ofMicrobiology resource announcements · 2025Article
- The Kocurious case of Noodlococcus: genomic insights intoMicrobial genomics · 2025Article
- Why Do FilamentousAnnual review of microbiology · 2025Review
- Genome sequence ofMicrobiology resource announcements · 2025Article
- Genomes of 211 Actinomycete Strains from Diverse Environments.Scientific data · 2025Article
- Article
- Exploring new natural products by utilizing untapped secondary metabolic pathways in actinomycetes.Journal of natural medicines · 2025Review
- Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.Annals of clinical microbiology and antimicrobials · 2025Article
- Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A.World journal of microbiology & biotechnology · 2025Article
- Enabling Access to Novel Bacterial Biosynthetic Potential From ONT Draft Genomic Data.Microbial biotechnology · 2025Article
- Pangenome mining of the Streptomyces genus redefines species' biosynthetic potential.Genome biology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Filamentous Actinobacteria, recently renamed Actinomycetia, are the most prolific source of microbial bioactive natural products. Studies on biosynthetic gene clusters benefit from or require chromosome-level assemblies. Here, we provide DNA sequences from >1000 isolates: 881 complete genomes and 153 near-complete genomes, representing 28 genera and 389 species, including 244 likely novel species. All genomes are from filamentous isolates of the class Actinomycetia from the NBC culture collection. The largest genus is Streptomyces with 886 genomes including 742 complete assemblies. We use this data to show that analysis of complete genomes can bring biological understanding not previously derived from more fragmented sequences or less systematic datasets. We document the central and structured location of core genes and distal location of specialized metabolite biosynthetic gene clusters and duplicate core genes on the linear Streptomyces chromosome, and analyze the content and length of the terminal inverted repeats which are characteristic for Streptomyces. We then analyze the diversity of trans-AT polyketide synthase biosynthetic gene clusters, which encodes the machinery of a biotechnologically highly interesting compound class. These insights have both ecological and biotechnological implications in understanding the importance of high quality genomic resources and the complex role synteny plays in Actinomycetia biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.