Evidence map›Paper›PMID 38907927›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Epitranscriptomic Mass Spectrometry.

Hongzhou Wang, Frank Morales Shnaider, Elizabeth Martin, Norman H L Chiu

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hongzhou Wang *Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC, USA.
Frank Morales Shnaider *Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC, USA.
Elizabeth Martin *Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC, USA.
Norman H L ChiuDepartment of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC, USA. nhchiu@uncg.edu.

Funding

Epitranscriptome Associated with Glioblastoma Therapeutic ResistanceR21NS118917 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHIU, NORMAN H. L., TANNOUS, BAKHOS A · 2020 to 2020
$451k
NINDS NIH HHS R21 NS118917
6 · The paper itself

Abstract

Every chemical group that is added to any one of the canonical ribonucleotides in a transcript would create a specific RNA modification. Currently, 170+ RNA modifications have been identified. A specific epitranscriptome refers to all the RNA modifications in a given biological system and is considered to play an important role in the regulations of cellular activities. Mass spectrometry-based methods have proven to be the most accurate way to identify RNA modifications and determine the amount of each detectable modification. Relating to the recent development of mapping specific RNA modifications within a transcriptome, the profiling of all RNA modifications can serve as a prescreening tool for mapping and provides support for analyzing the data obtained from mapping. In this chapter, the details for setting up a commonly used mass spectrometry-based method to profile all the RNA modifications in specific epitranscriptomes are described, and the possible options if available are discussed.

Indexed as

Mass SpectrometryRNARNA Processing, Post-TranscriptionalTranscriptomeEpigenesis, GeneticEpigenomicsGene Expression ProfilingHumansRNAEpitranscriptomeMass spectrometryRNA modifications

Identifiers

PMID38907927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.