Evidence map›Paper›PMID 38907857›Full record

ArticleInflammopharmacology2024

Topical diosmetin attenuates nociception and inflammation in a ultraviolet B radiation-induced sunburn model in mice.

Amanda Favarin, Gabriela Becker, Evelyne Silva Brum, Patrick Tuzi Serafini, Lara Panazzolo Marquezin, Indiara Brusco, Sara Marchesan Oliveira

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda FavarinLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Gabriela BeckerLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Evelyne Silva BrumLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Patrick Tuzi SerafiniLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Lara Panazzolo MarquezinLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Indiara BruscoLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Sara Marchesan OliveiraLaboratory of Neurotoxicity and Psychopharmacology - Pain Research Group, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. saramarchesan@ufsm.br.ORCID http://orcid.org/0000-0003-2960-5284

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #150611/2022-6Conselho Nacional de Desenvolvimento Científico e Tecnológico #309404/2023-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #88887.568915/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Grant #1333/2023Coordenação de Aperfeiçoamento de Pessoal de Nível Superior process #88881.844988/2023-01Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul #21/2551-0001966-2
6 · The paper itself

Abstract

Burns are a global health problem and can be caused by several factors, including ultraviolet (UV) radiation. Exposure to UVB radiation can cause sunburn and a consequent inflammatory response characterised by pain, oedema, inflammatory cell infiltration, and erythema. Pharmacological treatments available to treat burns and the pain caused by them include nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, antimicrobials and glucocorticoids, which are associated with adverse effects. Therefore, the search for new therapeutic alternatives is needed. Diosmetin, an aglycone of the flavonoid diosmin, has antinociceptive, antioxidant and anti-inflammatory properties. Thus, we evaluated the antinociceptive and anti-inflammatory effects of topical diosmetin (0.01, 0.1 and 1%) in a UVB radiation-induced sunburn model in mice. The right hind paw of the anaesthetised mice was exposed only once to UVB radiation (0.75 J/cm

Indexed as

Anti-Inflammatory AgentsDisease Models, AnimalFlavonoidsInflammationNociceptionSunburnUltraviolet RaysAdministration, TopicalAnalgesicsAnimalsEdemaHyperalgesiaMaleMiceAnalgesicsAnti-Inflammatory AgentsdiosmetinFlavonoidsAnti-inflammatoryAntinociceptionBurnNatural compoundPain

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.