ArticleAnnals of nuclear medicine2024
New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map.
Article in Annals of nuclear medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Whole-brain histogram analysis and top 20% gray and white matter ratio of amyloid positron emission tomography: A comparison with the centiloid scale.Annals of nuclear medicine · 2026Article
- A new amyloid PET evaluation method using separated gray-matter histogram based on three-component model.Annals of nuclear medicine · 2026Article
- Imaging of cardiac amyloidosis using dynamicAnnals of nuclear medicine · 2025Article
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14 authors.
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Abstract
objectiveThis study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses.
methodsTwenty-five healthy volunteers (HV) and 38 patients with diagnosed or suspected dementia who had undergone
resultsIn visual analysis, 32, 9, and 22 subjects showed negative, border, and positive results, and composed SUVR in each group were 1.11 ± 0.06, 1.20 ± 0.13, and 1.48 ± 0.18 (p < 0.0001), respectively. Visually positive subjects showed significantly low skewness and high MMR (p < 0.0001), and the Top20%-Map showed the presence or absence of abnormal deposits clearly. In comparison between the two tracers, visual evaluation was all consistent, and the ComSUVR, the skewness, the MMR showed significant good correlation. The Top20%-Maps showed similar pattern.
conclusionsOur new methods using the histogram of the brain parenchymal accumulation are simple and suitable for clinical practice of amyloid PET, and Top20%-Map on the individual's brain CT can be of great help for the visual assessment.
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