Evidence map›Paper›PMID 38907829›Full record

ArticleBiological trace element research2025

Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout.

Anatoly V Skalny, Tatiana V Korobeinikova, Tatiana I Sotnikova, Serafima Ia Tazina, Galina D Morozova, Xiong Guo, Feng Zhang, Sergey V Nekhoroshev, Yujie Ning, Alexey A Tinkov

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Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Anatoly V SkalnyCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia. skalny3@gmail.com.
Tatiana V KorobeinikovaCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Tatiana I SotnikovaCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Serafima Ia TazinaCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Galina D MorozovaCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Xiong GuoKey Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Health Science Center, School of Public Health, Xi'an Jiaotong University, Xi'an, 710061, China.
Feng ZhangKey Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Health Science Center, School of Public Health, Xi'an Jiaotong University, Xi'an, 710061, China.
Sergey V NekhoroshevKhanty-Mansiysk State Medical Academy, Khanty-Mansiysk, 628011, Russia.
Yujie NingKey Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Health Science Center, School of Public Health, Xi'an Jiaotong University, Xi'an, 710061, China.
Alexey A TinkovCenter of Bioelementology and Human Ecology, and Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.

Funding

National Natural Science Foundation of China 82361138566Russian Science Foundation 24-45-00073
6 · The paper itself

Abstract

The objective of the present study was to evaluate hair levels of toxic and essential trace elements and minerals in male and female patients with chronic gout. A total of 223 examinees aged from 27 to 82 years old including 116 healthy controls (64 women and 52 men) and 107 patients with gout (56 women and 51 men) were enrolled in the current cross-sectional study. Analysis of hair toxic and essential trace element and mineral content was performed using inductively-coupled plasma mass-spectrometry. The obtained data demonstrate that hair B, Fe, I, and Mo levels in gout patients were 67%, 8%, 46%, and 21% higher in comparison to the respective control values. Hair Cr and V content in patients was more than twofold higher than in the controls. Hair Mg and Zn levels were found to be 34% and 11% lower when compared to the respective control values. Hair toxic metal and metalloid content was also significantly affected in gout patients. Specifically, hair Al, As, and Pb levels were 24%, 43%, and 33% higher in gout patients than in healthy controls, respectively. Analysis of covariance demonstrated that sex also had a significant influence on hair trace element and mineral levels in gout patients. Specifically, gout-associated overaccumulation of hair trace elements including was more profound in male than in female patients. It is assumed that trace element dysregulation may contribute to gout development and progression, especially in men. However, further studies are required to elucidate this association and the underlying molecular mechanisms.

Indexed as

GoutHairMineralsTrace ElementsAdultAgedAged, 80 and overChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedMineralsTrace ElementsEssential trace elementsHair samplesMineralsNutritional diseasesToxic trace elements

Identifiers

PMID38907829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.