Evidence map›Paper›PMID 38907772›Full record

ArticleForensic science, medicine, and pathology2025

Dura mater and survival time determination in individuals who died after traumatic brain injury: a preliminary study.

Marcello Benevento, Antonio d'Amati, Simona Nicolì, Laura Ambrosi, Jacek Baj, Davide Ferorelli, Giuseppe Ingravallo, Biagio Solarino

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Article in Forensic science, medicine, and pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcello BeneventoSection of Legal Medicine, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy. m.benevento3@studenti.uniba.it.ORCID 0000-0002-4895-0182
Antonio d'AmatiSection of Pathology, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.
Simona NicolìSection of Legal Medicine, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.
Laura AmbrosiSection of Legal Medicine, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.
Jacek BajChair and Department of Anatomy, Medical University of Lublin, Lublin, 20-090, Poland.
Davide FerorelliSection of Legal Medicine, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.
Giuseppe IngravalloSection of Pathology, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.
Biagio SolarinoSection of Legal Medicine, University of Bari, piazza Giulio Cesare, 11, Bari, 70124, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) is one of the major causes of morbidity and mortality among young people and is a matter of concern for forensic pathologists. Many authors have tried to estimate a person's survival time (ST) after TBI using different approaches.

objectiveThe present study aimed to present an innovative workflow to estimate the ST after TBI by observing the inflammatory reaction of the dura mater (DM).

methodsThe authors collected DM samples from 36 cadavers (20 with TBI and 16 with no history or signs of TBI). Each sample was labelled via immunohistochemistry with three different primary antibodies, CD15, CD68, and CD3, yielding 108 slides in total. The slides were digitalized and analysed using QuPath software.

resultsThe DM is involved in the inflammatory response after TBI. CD15 immunoreactivity allowed us to distinguish between subjects who died immediately after TBI and those with an ST of minutes or hours. CD3 immunoreactivity can be used to differentiate subjects with an ST of days from those with other STs. Moreover, the DM samples showed an acceptable diagnostic yield even in samples with signs of putrefaction.

Indexed as

Brain Injuries, TraumaticDura MaterAdolescentAdultAgedAged, 80 and overAntigens, CDAntigens, Differentiation, MyelomonocyticCase-Control StudiesCD3 ComplexCD68 MoleculeFemaleForensic PathologyHumansImmunohistochemistryMaleAntigens, CDAntigens, Differentiation, MyelomonocyticCD3 ComplexCD68 antigen, humanCD68 MoleculeDura materSurvival timeTraumatic brain injury

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.