Evidence map›Paper›PMID 38907698›Full record

ArticleBiomacromolecules2024

Polyglycerol-Shelled Reduction-Sensitive Polymersome for DM1 Delivery to HER-2-Positive Breast Cancer.

Guoxin Ma, Daniel Braatz, Peng Tang, Yian Yang, Elisa Quaas, Kai Ludwig, Nan Ma, Huanli Sun, Zhiyuan Zhong, Rainer Haag

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bioactive Polysulfate-Based Nano-Assemblies Against Virus Infection.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guoxin MaInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Daniel BraatzInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Peng TangInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Yian YangInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Elisa QuaasInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Kai LudwigInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.
Nan MaInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.ORCID 0000-0003-4006-1003
Huanli SunBiomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, PR China.ORCID 0000-0001-6287-1555
Zhiyuan ZhongBiomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, PR China.ORCID 0000-0003-4175-4741
Rainer HaagInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany.ORCID 0000-0003-3840-162X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supramolecular delivery systems with the prolonged circulation, the potential for diverse functionalization, and few toxin-related limitations have been extensively studied. For the present study, we constructed a linear polyglycerol-shelled polymersome attached with the anti-HER-2-antibody trastuzumab. We then covalently loaded the anticancer drug DM1 in the polymersome via dynamic disulfide bonding. The resulted trastuzumab-polymersome-DM1 (Tra-PS-DM1) exhibits a mean size of 95.3 nm and remarkable drug loading efficiency % of 99.3%. In addition to its superior stability, we observed the rapid release of DM1 in a controlled manner under reductive conditions. Compared to the native polymersomes, Tra-PS-DM1 has shown greatly improved cellular uptake and significantly reduced IC

Indexed as

Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesGlycerolPolymersTrastuzumabAdo-Trastuzumab EmtansineCell Line, TumorDrug Delivery SystemsFemaleHumansAdo-Trastuzumab EmtansineERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGlycerolpolyglycerolPolymersTrastuzumab

Identifiers

PMID38907698
PMCPMC11238329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.