Evidence map›Paper›PMID 38907290›Full record

ArticleHereditas2024

Comparative pharmacognosy and secondary metabolite analysis of Balanophorae herbs from different sources.

Xueyan Zhao, Lihui Zheng, Qingxin Shi, Yuqi Lin, Zhaoxiang Zeng, Chengwu Song, Shuna Jin, Ling Xiao

Abstract readComparative Study
In one paragraph

Article in Hereditas, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueyan Zhao *School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Lihui Zheng *Hubei Institute for Drug Control, Hubei Engineering Research Center for Drug Quality Control, NMPA Key Laboratory of Quality Control of Chinese Medicine, Wuhan, Hubei, 430075, China.
Qingxin Shi *School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Yuqi LinSchool of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Zhaoxiang ZengSchool of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Chengwu SongSchool of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Shuna JinSchool of Basic Medical Sciences, Hubei University of Chinese Medicine, HuangJiaHu West Road 16, Wuhan, Hubei, 430065, China. jinshuna2021@hbtcm.edu.cn.ORCID http://orcid.org/0000-0001-7760-2382
Ling XiaoHubei Institute for Drug Control, Hubei Engineering Research Center for Drug Quality Control, NMPA Key Laboratory of Quality Control of Chinese Medicine, Wuhan, Hubei, 430075, China. Lingyun724@126.com.

Funding

Hubei Province Technology Innovation Project 2020ACA007Natural Science Foundation of Hubei Province 2022CFB486Youth scientific research fund of Hubei Institute for Drug Control 2022YN008
6 · The paper itself

Abstract

The Balanophorae are not only traditional Chinese herbal medicines but also functional foods with diverse sources. This study aimed to distinguish pharmacognostic characteristics and secondary metabolites among different species of Balanophorae. Eight species of Balanophorae herbs were harvested, including 21 batches with 209 samples. Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used to analyze secondary metabolites of Balanophorae from 21 sources. Targeted metabolomic analysis was performed to compare differences among the groups. Rhopalocnemis phalloide and B. indica can be identified by their pharmacognostic characteristics. Then, 41 secondary metabolites were identified or characterized in the mixed extracts of the 209 samples, mainly phenolic acids, flavonoids, and their derivatives. The distribution of these secondary metabolites revealed apparent differences among different species. In addition, targeted metabolomic analysis suggested that the secondary metabolite profiles of seven species of Balanophorae showed noticeable differences, and differences were also observed among different growing regions. Finally, five important metabolic markers were screened to successfully distinguish B. laxiflora, B. harlandii, and B. polyandra, including three phenolic acids and two flavonoids. This is the first study to systematically compare both the morphology and secondary metabolites among different sources of Balanophorae, which could provide effective information for identifying diverse species.

Indexed as

MetabolomicsChromatography, High Pressure LiquidDrugs, Chinese HerbalFlavonoidsHydroxybenzoatesMass SpectrometryMetabolomePharmacognosyPlant ExtractsSecondary MetabolismDrugs, Chinese HerbalFlavonoidsHydroxybenzoatesPlant ExtractsBalanophoraeLC-MSPharmacognosySecondary metabolitesTargeted metabolomics

Identifiers

PMID38907290
PMCPMC11191205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.