Evidence map›Paper›PMID 38907121›Full record

ArticleBiological trace element research2025

Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults.

Feng Li, Liqin Su, Ranqi Shao, Jiao Luo, Yi Chen, Yifeng Huang, Minghai Wei, Jiliang Zhang, Yumei Gao, Kui Ma and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Feng LiChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Liqin SuChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China. suliqin@nieh.chinacdc.cn.
Ranqi ShaoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Jiao LuoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Yi ChenQionglai Center for Disease Control and Prevention, Chengdu, 611530, China.
Yifeng HuangGaomi Center for Disease Control and Prevention, Weifang, 261500, China.
Minghai WeiJiange Center for Disease Control and Prevention, Guangyuan, 628317, China.
Jiliang ZhangZichuan Center for Disease Control and Prevention, Zibo, 255100, China.
Yumei GaoZichuan Center for Disease Control and Prevention, Zibo, 255100, China.
Kui MaHubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China.
Xiyao LiuNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, Beijing, 100050, China.
Weihao XiChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, 46202-2872, USA.

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3M
Selenium, other risk factors and cognitive decline in rural elderly ChineseR01AG019181 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GAO, SUJUAN · 2003 to 2014
$4.1M
Academic Leadership Award for Statistical Training in Multidisciplinary Aging ResearchK07AG076659 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI SUJUAN GAO · 2022 to 2026
$777k
NIA NIH HHS K07 AG076659NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019181
6 · The paper itself

Abstract

Selenium (Se) is physiologically essential for thyroid function. However, epidemiological studies on the association between Se status and thyroid function are limited and the results are inconsistent. Therefore, we explored this association in an elderly Chinese population sample. Participants in the cross-sectional study were people aged 65 years or older who provided fingernail and whole blood samples. Hyperthyroidism and hypothyroidism were defined by serum thyroid hormones concentrations, including thyroid stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT3), and free thyrotropin (FT4). Significant positive association was observed between whole blood and fingernail Se concentrations (r = 0.672, P < 0.001). Compared with the lowest Se quartile (Q1), the other fingernail Se quartile groups had lower TSH, higher FT3 and FT4 levels, and Q2 had higher TT3 levels after adjusting for covariates; the other whole blood Se quartile groups had lower TSH levels, Q2 had higher FT3, FT4 and TT3 levels, Q3 had higher FT3 levels, and Q4 had higher FT4 levels after adjusting for covariates. Compared with Q1, the adjusted odds ratios (OR) and 95% confidence intervals (95%CIs) of hypothyroidism for Q4 of whole blood Se was 0.141 (0.029,0.675), and the adjusted OR (95%CIs) of hyperthyroidism for Q2 and Q3 of fingernail Se were 4.121 (1.233,13.733) and 3.614 (1.095,11.926). Higher Se levels were significantly associated with lower TSH levels and higher levels of TT3, FT3 and FT4. Meanwhile, higher Se levels were associated with lower risk of hypothyroidism and higher risk of hyperthyroidism.

Indexed as

HyperthyroidismHypothyroidismSeleniumThyroid GlandThyroid HormonesAgedAged, 80 and overChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansMaleThyrotropinThyroxineTriiodothyronineSeleniumThyroid HormonesThyrotropinThyroxineTriiodothyronineFingernailSeleniumThyroid dysfunctionThyroid hormoneWhole blood

Identifiers

PMID38907121
PMCPMC12795597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.